The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Small-Molecule Inhibitor of Vibrio cholerae Virulence and Intestinal Colonization
Abstract
Increasing antibiotic resistance requires the development of new approaches to combating infection. Virulence gene expression in vivo represents a target for antibiotic discovery that has not yet been explored. A high-throughput, phenotypic screen was used to identify a small molecule 4-[ N -(1,8-naphthalimide)]- n -butyric acid, virstatin, that inhibits virulence regulation in Vibrio cholerae . By inhibiting the transcriptional regulator ToxT, virstatin prevents expression of two critical V. cholerae virulence factors, cholera toxin and the toxin coregulated pilus. Orogastric administration of virstatin protects infant mice from intestinal colonization by V. cholerae .
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A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191
Cited by
Antibiotic resistance-the need for global solutions
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70318-9 · Cited by 4,439
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities
Cushnie, T. P. T., Cushnie, B., & Lamb, A. J. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.06.001 · Cited by 894
The biology and future prospects of antivirulence therapies
Cegelski, L., Marshall, G. R., Eldridge, G. R., & Hultgren, S. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1818 · Cited by 788
Antibiotic Resistance: One Health One World Outlook
Aslam, B., Khurshid, M., Arshad, M. I., Muzammil, S., Rasool, M., Yasmeen, N., Shah, T., Chaudhry, T. H., Rasool, M. H., Shahid, A., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.771510 · Cited by 609
Metadata
- Authors
- Hung, D. T., Shakhnovich, E. A., Pierson, E., & Mekalanos, J. J.
- Venue
- Science
- Published
- 2005-10-28
- Volume
- 310
- Issue
- 5748
- Pages
- 670-674
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086036297
- Cited by
- 358
- References
- 1
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hung, D. T., Shakhnovich, E. A., Pierson, E., & Mekalanos, J. J. (2005). Small-Molecule Inhibitor of Vibrio cholerae Virulence and Intestinal Colonization. Science. https://doi.org/10.1126/science.1116739
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