The DOI matches its Crossref record.
Wingless Signaling at Synapses Is Through Cleavage and Nuclear Import of Receptor DFrizzled2
Open accessAbstract
Wingless secretion provides pivotal signals during development by activating transcription of target genes. At Drosophila synapses, Wingless is secreted from presynaptic terminals and is required for synaptic growth and differentiation. Wingless binds the seven-pass transmembrane DFrizzled2 receptor, but the ensuing events at synapses are not known. We show that DFrizzled2 is endocytosed from the postsynaptic membrane and transported to the nucleus. The C terminus of DFrizzled2 is cleaved and translocated into the nucleus; the N-terminal region remains just outside the nucleus. Translocation of DFrizzled2-C into the nucleus, but not its cleavage and transport, depends on Wingless signaling. We conclude that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
LRP4 serves as a coreceptor of Agrin
Zhang, B., Luo, S., Wang, Q., Suzuki, T., Xiong, W. C., & Mei, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.006 · Cited by 525
Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless
Korkut, C., Ataman, B., Ramachandran, P., Ashley, J., Barria, R., Gherbesi, N., & Budnik, V. (2009) · Cell · doi:10.1016/j.cell.2009.07.051 · Cited by 443
Self-citationWillert, K., & Nusse, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007864 · Cited by 353
Speese, S. D., Ashley, J., Jokhi, V., Nunnari, J., Barria, R., Li, Y., Ataman, B., Koon, A., Chang, Y.-T., Li, Q., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.032 · Cited by 317
Self-citationWnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274
Metadata
- Authors
- Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S., & Budnik, V.
- Venue
- Science
- Published
- 2005-11-25
- Volume
- 310
- Issue
- 5752
- Pages
- 1344-1347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994227710
- Cited by
- 186
- References
- 0
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Wingless Signaling at Synapses Is Through Cleavage and Nuclear Import of Receptor DFrizzled2. https://app.cochat.ai/papers/10.1126/science.1117051
- The paper
- Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S., & Budnik, V. (2005). Wingless Signaling at Synapses Is Through Cleavage and Nuclear Import of Receptor DFrizzled2. Science. https://doi.org/10.1126/science.1117051
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
