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Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

Korkut, Ceren, Ataman, Bulent, Ramachandran, Preethi, Ashley, James, Barria, Romina, Gherbesi, Norberto, Budnik, Vivian·2009·Cell
DOI 10.1016/j.cell.2009.07.051PMC PMC2785045
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Crossref · 10.1016/j.cell.2009.07.051

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  • Motor neuron terminals in Drosophila larvae release exosomes to promote maturation of neuromuscular junctions.

    “motor neuron terminals in Drosophila larvae release exosomes to promote the maturation of neuromuscular junctions11,18.”

    From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [18]

  • In vivo studies in Drosophila larvae showed motor neurons can secrete Wingless-associated and Synaptotagmin 4-containing exosomes to promote synaptic development and plasticity.

    “In vivo studies in Drosophila larvae showed that motor neurons can secrete Wingless-associated and Synaptotagmin 4-containing exosomes to promote the synaptic development and plasticity11,18.”

    From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [18]

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Research works printed but not linked: 35

  1. Ataman B Ashley J Gorczyca D Gorczyca M Mathew D Wichmann C Sigrist SJ Budnik V Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP Proc Natl Acad Sci U S A 2006 103 7841 7846 16682643 PMC1472532
  2. Ataman B Ashley J Gorczyca M Ramachandran P Fouquet W Sigrist SJ Budnik V Rapid activity-dependent modifications in synaptic structure and function require bidirectional wnt signaling Neuron 2008 57 705 718 18341991 PMC2435264
  3. Baeg GH Lin X Khare N Baumgartner S Perrimon N Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless Development 2001 128 87 94 11092814
  4. Banziger C Soldini D Schutt C Zipperlen P Hausmann G Basler K Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells Cell 2006 125 509 522 16678095
  5. Belenkaya TY Wu Y Tang X Zhou B Cheng L Sharma YV Yan D Selva EM Lin X The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network Dev Cell 2008 14 120 131 18160348
  6. Budnik V Koh YH Guan B Hartmann B Hough C Woods D Gorczyca M Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg Neuron 1996 17 627 640 8893021 PMC4661176
  7. Coudreuse DY Roel G Betist MC Destree O Korswagen HC Wnt gradient formation requires retromer function in Wnt-producing cells Science 2006 312 921 924 16645052
  8. De Ferrari GV Moon RT The ups and downs of Wnt signaling in prevalent neurological disorders Oncogene 2006 25 7545 7553 17143299
  9. Fevrier B Raposo G Exosomes: endosomal-derived vesicles shipping extracellular messages Curr Opin Cell Biol 2004 16 415 421 15261674
  10. Franch-Marro X Wendler F Guidato S Griffith J Baena-Lopez A Itasaki N Maurice MM Vincent JP Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex Nat Cell Biol 2008 10 170 177 18193037 PMC7611556
  11. Franco B Bogdanik L Bobinnec Y Debec A Bockaert J Parmentier ML Grau Y Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila J Neurosci 2004 24 6573 6577 15269269 PMC6729875
  12. Gagliardi M Piddini E Vincent JP Endocytosis: a positive or a negative influence on Wnt signalling? Traffic 2008 9 1 9 17908284
  13. Goodman RM Thombre S Firtina Z Gray D Betts D Roebuck J Spana EP Selva EM Sprinter: a novel transmembrane protein required for Wg secretion and signaling Development 2006 133 4901 4911 17108000
  14. Greco V Hannus M Eaton S Argosomes: a potential vehicle for the spread of morphogens through epithelia Cell 2001 106 633 645 11551510
  15. Lyu J Yamamoto V Lu W Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis Dev Cell 2008 15 773 780 19000841
  16. Marques G Morphogens and synaptogenesis in Drosophila J Neurobiol 2005 64 417 434 16041756
  17. Mathew D Ataman B Chen J Zhang Y Cumberledge S Budnik V Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2 Science 2005 310 1344 1347 16311339 PMC3535279
  18. Mendoza-Topaz C Urra F Barria R Albornoz V Ugalde D Thomas U Gundelfinger ED Delgado R Kukuljan M Sanxaridis PD DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function J Neurosci 2008 28 304 314 18171947 PMC4656021
  19. Miech C Pauer HU He X Schwarz TL Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction J Neurosci 2008 28 10875 10884 18945895 PMC2597682
  20. Neumann CJ Cohen SM Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing Development 1997 124 871 880 9043068
  21. Packard M Koo ES Gorczyca M Sharpe J Cumberledge S Budnik V The Drosophila wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation Cell 2002 111 319 330 12419243 PMC3499980
  22. Pan CL Baum PD Gu M Jorgensen EM Clark SG Garriga G C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless Dev Cell 2008 14 132 139 18160346 PMC2709403
  23. Panakova D Sprong H Marois E Thiele C Eaton S Lipoprotein particles are required for Hedgehog and Wingless signalling Nature 2005 435 58 65 15875013
  24. Pielage J Fetter RD Davis GW Presynaptic spectrin is essential for synapse stabilization Curr Biol 2005 15 918 928 15916948
  25. Port F Kuster M Herr P Furger E Banziger C Hausmann G Basler K Wingless secretion promotes and requires retromer-dependent cycling of Wntless Nat Cell Biol 2008 10 178 185 18193032
  26. Sanyal S Narayanan R Consoulas C Ramaswami M Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity BMC Neurosci 2003 4 20 12969508 PMC201019
  27. Selkoe DJ Yamazaki T Citron M Podlisny MB Koo EH Teplow DB Haass C The role of APP processing and trafficking pathways in the formation of amyloid beta-protein Ann N Y Acad Sci 1996 777 57 64 8624127
  28. Siegfried E Perrimon N Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling Bioessays 1994 16 395 404 8080429
  29. Speese SD Budnik V Wnts: up-and-coming at the synapse Trends Neurosci 2007 30 268 275 17467065 PMC3499976
  30. Torroja L Chu H Kotovsky I White K Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport Curr Biol 1999 9 489 492 10322116
  31. van den Heuvel M Nusse R Johnston P Lawrence PA Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication Cell 1989 59 739 749 2582493
  32. van Niel G Porto-Carreiro I Simoes S Raposo G Exosomes: a common pathway for a specialized function J Biochem 2006 140 13 21 16877764
  33. Yang PT Lorenowicz MJ Silhankova M Coudreuse DY Betist MC Korswagen HC Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells Dev Cell 2008 14 140 147 18160347
  34. Zhai L Chaturvedi D Cumberledge S Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine J Biol Chem 2004 279 33220 33227 15166250
  35. Zhao C Aviles C Abel RA Almli CR McQuillen P Pleasure SJ Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval Development 2005 132 2917 2927 15930120

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Sorted by citations

Authors
Korkut, C., Ataman, B., Ramachandran, P., Ashley, J., Barria, R., Gherbesi, N., & Budnik, V.
Venue
Cell
Publisher
Elsevier BV
Published
2009-10
Volume
139
Issue
2
Pages
393-404
ISSN
0092-8674
DOI
10.1016/j.cell.2009.07.051
PMC
PMC2785045
Cited by
396
References
5
Language
en
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