The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytokinin Signaling and Its Inhibitor AHP6 Regulate Cell Fate During Vascular Development
Abstract
The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.
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Citations
Cites
Regulation of plant growth by cytokinin
Werner, T., Motyka, V., Strnad, M., & Schmülling, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171304098 · Cited by 1,133
Cited by
Cell Signalling by MicroRNA165/6 Directs Gene Dose-Dependent Root Cell Fate
Carlsbecker, A., Lee, J.-Y., Roberts, C. J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M. A., Vatén, A., Thitamadee, S., et al. (2010) · Nature · doi:10.1038/nature08977 · Cited by 861
Self-citationArabidopsis lateral root development: an emerging story
Péret, B., De Rybel, B., Casimiro, I., Benková, E., Swarup, R., Laplaze, L., Beeckman, T., & Bennett, M. J. (2009) · Trends in Plant Science · doi:10.1016/j.tplants.2009.05.002 · Cited by 818
The Plant Vascular System: Evolution, Development and Functions F
Lucas, W. J., Groover, A., Lichtenberger, R., Furuta, K., Yadav, S., Helariutta, Y., He, X., Fukuda, H., Kang, J., Brady, S. M., et al. (2013) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12041 · Cited by 772
Self-citationCytokinin signaling in plant development
Kieber, J. J., & Schaller, G. E. (2018) · Development · doi:10.1242/dev.149344 · Cited by 758
Bartrina, I., Otto, E., Strnad, M., Werner, T., & Schmülling, T. (2011) · The Plant Cell · doi:10.1105/tpc.110.079079 · Cited by 697
Metadata
- Authors
- Mähönen, A. P., Bishopp, A., Higuchi, M., Nieminen, K. M., Kinoshita, K., Törmäkangas, K., Ikeda, Y., Oka, A., Kakimoto, T., & Helariutta, Y.
- Venue
- Science
- Published
- 2006-01-06
- Volume
- 311
- Issue
- 5757
- Pages
- 94-98
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088824594
- Cited by
- 618
- References
- 1
- FWCI
- 34.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cytokinin Signaling and Its Inhibitor AHP6 Regulate Cell Fate During Vascular Development. https://app.cochat.ai/papers/10.1126/science.1118875
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- Mähönen, A. P., Bishopp, A., Higuchi, M., Nieminen, K. M., Kinoshita, K., Törmäkangas, K., Ikeda, Y., Oka, A., Kakimoto, T., & Helariutta, Y. (2006). Cytokinin Signaling and Its Inhibitor AHP6 Regulate Cell Fate During Vascular Development. Science. https://doi.org/10.1126/science.1118875
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