The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Probing Cellular Chemistry in Biological Systems with Microelectrodes
Abstract
Over the past 20 years, the technological impediments to fabricating electrodes of micrometer dimensions have been largely overcome. These small electrodes can be readily applied to probe chemical events at the surface of tissues or individual biological cells; they can even be used to monitor concentration changes within intact animals. These measurements can be made on rapid time scales and with minimal perturbation of the system under study. Several recent applications have provided important insights into chemical processes at cells and in tissues. Examples include molecular flux measurements at the surface of single cells and through skin—which can offer insights into oxidative stress, exocytosis, and drug delivery—and real-time brain neurotransmitter monitoring in living rats, which reveals correlations between behavior and molecular events in the brain. Such findings can promote interdisciplinary collaborations and may lead to a broader understanding of the chemical aspects of biology.
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Cites
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113
Self-citationWightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Self-citationReal-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats
Heien, M. L. A. V., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., Wassum, K. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504657102 · Cited by 482
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Cited by
Advanced Carbon Electrode Materials for Molecular Electrochemistry
McCreery, R. L. (2008) · Chemical Reviews · doi:10.1021/cr068076m · Cited by 2,729
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976
Efficient water oxidation at carbon nanotube–polyoxometalate electrocatalytic interfaces
Toma, F. M., Sartorel, A., Iurlo, M., Carraro, M., Parisse, P., Maccato, C., Rapino, S., Gonzalez, B. R., Amenitsch, H., Da Ros, T., et al. (2010) · Nature Chemistry · doi:10.1038/nchem.761 · Cited by 503
Current Transients in Single Nanoparticle Collision Events
Xiao, X., Fan, F.-R. F., Zhou, J., & Bard, A. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8051393 · Cited by 451
Hydrogel Based Sensors for Biomedical Applications: An Updated Review
Tavakoli, J., & Tang, Y. (2017) · Polymers · doi:10.3390/polym9080364 · Cited by 434
Metadata
- Authors
- Wightman, R. M.
- Venue
- Science
- Published
- 2006-03-17
- Volume
- 311
- Issue
- 5767
- Pages
- 1570-1574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2111710127
- Cited by
- 439
- References
- 3
- FWCI
- 25.66
- Type
- journal article
- Language
- en
- Open access
- closed
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