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Cited by 482Neurotransmitter Receptor Influence on BehaviorElectrochemical Analysis and ApplicationsElectrochemical sensors and biosensors

Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats

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Heien, Michael L. A. V., Khan, Amina S., Ariansen, Jennifer L., Cheer, Joseph F., Phillips, Paul E. M., Wassum, Kate M., Wightman, R. Mark·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0504657102PMC PMC1177422
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Abstract

Dopamine neurotransmission has been implicated in the modulation of many cognitive processes. Both rapid (phasic) and slower (tonic) changes in its extracellular concentration contribute to its complex actions. Fast in vivo electrochemical techniques can measure extracellular dopamine on a rapid time scale but without the selectivity afforded with slower techniques that use chemical separations. Cyclic voltammetry improves chemical resolution over other electrochemical methods, and it can resolve dopamine changes in the brains of behaving rodents over short epochs (<10 s). With this method, however, selective detection of slower dopamine changes is still elusive. Here we demonstrate that principal component regression of cyclic voltammetry data enables quantification of changes in dopamine and extracellular pH. Using this method, we show that cocaine modifies dopamine release in two ways: dopamine concentration transients increase in frequency and magnitude, whereas a gradual increase in steady-state dopamine concentration occurs over 90 s.

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  • Tonic signals influence phasic signals and vice versa; systemic administration of cocaine increases tonic dopamine signals by blocking dopamine uptake and also increases frequencies of phasic signals and transients.

    “It is not easy to investigate functional roles of phasic and tonic dopamine signaling because tonic signals influence phasic signals and vice versa; systemic administration of cocaine, which increases tonic dopamine signals by blocking dopamine uptake, also increases frequencies of phasic signals and transients as detected by the fast-scan cyclic voltammetry (Heien et al., 2005; Stuber et al., 200”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Heien et al., 2005

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Authors
Heien, M. L. A. V., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., Wassum, K. M., & Wightman, R. M.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2005-07-08
Volume
102
Issue
29
Pages
10023-10028
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0504657102
PMC
PMC1177422
OpenAlex
W2096839627
Cited by
482
References
48
Citations by year
2026: 6 · 2025: 14 · 2024: 22 · 2023: 17 · 2022: 20 · 2021: 26 · 2020: 26 · 2019: 26 · 2018: 31 · 2017: 25 · 2016: 37 · 2015: 42 · 2014: 27 · 2013: 30 · 2012: 27
FWCI
4.60
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
National Institute of Neurological Disorders and Stroke (NS 15841, R01NS015841)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
Keywords
dopamine, cocaine, dopamine release, cyclic voltammetry, principal component regression, extracellular pH, tonic dopamine, real-time measurement
MeSH terms
Animals, Brain, Cocaine, Dopamine, Electrochemistry, Hydrogen-Ion Concentration, Regression Analysis, Time Factors, Principal Component Analysis, Extracellular Fluid, Rats

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