The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
αE-Catenin Controls Cerebral Cortical Size by Regulating the Hedgehog Signaling Pathway
Open accessAbstract
During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system–specific deletion of the essential adherens junction gene, α E-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that αE-catenin connects cell-density–dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex.
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Citations
Cites
Hedgehog–GLI signaling and the growth of the brain
Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
Cited by
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342
Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036
Self-citationXiang, Y., Tanaka, Y., Patterson, B., Kang, Y.-J., Govindaiah, G., Roselaar, N., Cakir, B., Kim, K.-Y., Lombroso, A. P., Hwang, S.-M., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.07.007 · Cited by 698
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655
Structure and Biochemistry of Cadherins and Catenins
Shapiro, L., & Weis, W. I. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003053 · Cited by 462
Metadata
- Authors
- Lien, W.-H., Klezovitch, O., Fernandez, T. E., Delrow, J., & Vasioukhin, V.
- Venue
- Science
- Published
- 2006-03-17
- Volume
- 311
- Issue
- 5767
- Pages
- 1609-1612
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031928696
- Cited by
- 251
- References
- 1
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Lien, W.-H., Klezovitch, O., Fernandez, T. E., Delrow, J., & Vasioukhin, V. (2006). αE-Catenin Controls Cerebral Cortical Size by Regulating the Hedgehog Signaling Pathway. Science. https://doi.org/10.1126/science.1121449
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
