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Chromosomes Can Congress to the Metaphase Plate Before Biorientation
Open accessAbstract
The stable propagation of genetic material during cell division depends on the congression of chromosomes to the spindle equator before the cell initiates anaphase. It is generally assumed that congression requires that chromosomes are connected to the opposite poles of the bipolar spindle (“bioriented”). In mammalian cells, we found that chromosomes can congress before becoming bioriented. By combining the use of reversible chemical inhibitors, live-cell light microscopy, and correlative electron microscopy, we found that monooriented chromosomes could glide toward the spindle equator alongside kinetochore fibers attached to other already bioriented chromosomes. This congression mechanism depended on the kinetochore-associated, plus end–directed microtubule motor CENP-E (kinesin-7).
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Citations
Cited by
The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227
Self-citationMolecular architecture of the kinetochore–microtubule interface
Cheeseman, I. M., & Desai, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2310 · Cited by 915
Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1
Petronczki, M., Lénárt, P., & Peters, J.-M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.014 · Cited by 485
Kitajima, T. S., Ohsugi, M., & Ellenberg, J. (2011) · Cell · doi:10.1016/j.cell.2011.07.031 · Cited by 299
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E
Kim, Y., Holland, A. J., Lan, W., & Cleveland, D. W. (2010) · Cell · doi:10.1016/j.cell.2010.06.039 · Cited by 233
Metadata
- Authors
- Kapoor, T. M., Lampson, M. A., Hergert, P., Cameron, L., Cimini, D., Salmon, E. D., McEwen, B. F., & Khodjakov, A.
- Venue
- Science
- Published
- 2006-01-20
- Volume
- 311
- Issue
- 5759
- Pages
- 388-391
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140493627
- Cited by
- 439
- References
- 0
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Kapoor, T. M., Lampson, M. A., Hergert, P., Cameron, L., Cimini, D., Salmon, E. D., McEwen, B. F., & Khodjakov, A. (2006). Chromosomes Can Congress to the Metaphase Plate Before Biorientation. Science. https://doi.org/10.1126/science.1122142
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