The spindle-assembly checkpoint in space and time
Abstract
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores--structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
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Many genes implicated in chromosome segregation were among the top drivers of heterogeneity, including TTK, SPC25, and DSN1.
“many genes implicated in chromosome segregation were among the top drivers of heterogeneity, including TTK, SPC25, and DSN1”
From Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq (2022) · cites this paper as Musacchio and Salmon, 2007
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- Authors
- Musacchio, A., & Salmon, E. D.
- Affiliations
- Italian Institute of Technology (IT)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Musacchio, Andrea
- Salmon, Edward D.
- ORCID
- Musacchio, Andrea
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-04-11
- Volume
- 8
- Issue
- 5
- Pages
- 379-393
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2048938594
- Cited by
- 2,227
- References
- 1
- Citations by year
- 2026: 50 · 2025: 65 · 2024: 62 · 2023: 73 · 2022: 92 · 2021: 79 · 2020: 93 · 2019: 87 · 2018: 72 · 2017: 99 · 2016: 107 · 2015: 132 · 2014: 139 · 2013: 153 · 2012: 209
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Fondazione Cariplo
- National Institute of General Medical Sciences (R01GM060678, R37GM024364)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- spindle assembly checkpoint, kinetochore, chromosome segregation, mitosis, aneuploidy, checkpoint activation, checkpoint silencing, carcinogenesis
- MeSH terms
- Aneuploidy, Animals, Cell Cycle, Humans, Spindle Apparatus, Models, Biological, Neoplasms, Phosphotransferases, Time Factors, Kinetochores, Cell Cycle Proteins, Genes, cdc
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