The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Abstract
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, “top-down” influences on risk assessment.
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Cites
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Self-citationEarly-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
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Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
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Metadata
- Authors
- Weisstaub, N. V., Zhou, M., Lira, A., Lambe, E., González-Maeso, J., Hornung, J.-P., Sibille, E., Underwood, M., Itohara, S., Dauer, W. T., Ansorge, M. S., Morelli, E., Mann, J. J., Toth, M., Aghajanian, G., Sealfon, S. C., Hen, R., & Gingrich, J. A.
- Venue
- Science
- Published
- 2006-07-28
- Volume
- 313
- Issue
- 5786
- Pages
- 536-540
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2104516271
- Cited by
- 425
- References
- 30
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weisstaub, N. V., Zhou, M., Lira, A., Lambe, E., González-Maeso, J., Hornung, J.-P., Sibille, E., Underwood, M., Itohara, S., Dauer, W. T., Ansorge, M. S., Morelli, E., Mann, J. J., Toth, M., Aghajanian, G., Sealfon, S. C., Hen, R., & Gingrich, J. A. (2006). Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice. Science. https://doi.org/10.1126/science.1123432
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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