The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity
Abstract
Evolutionary sequence conservation is an accepted criterion to identify noncoding regulatory sequences. We have used a transposon-based transgenic assay in zebrafish to evaluate noncoding sequences at the zebrafish ret locus, conserved among teleosts, and at the human RET locus, conserved among mammals. Most teleost sequences directed ret -specific reporter gene expression, with many displaying overlapping regulatory control. The majority of human RET noncoding sequences also directed ret -specific expression in zebrafish. Thus, vast amounts of functional sequence information may exist that would not be detected by sequence similarity approaches.
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Cites
Ultraconserved Elements in the Human Genome
Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W. J., Mattick, J. S., & Haussler, D. (2004) · Science · doi:10.1126/science.1098119 · Cited by 1,732
Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development
Woolfe, A., Goodson, M., Goode, D. K., Snell, P., McEwen, G. K., Vavouri, T., Smith, S. F., North, P., Callaway, H., Kelly, K., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0030007 · Cited by 970
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Dermitzakis, E. T., & Clark, A. G. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004169 · Cited by 463
Cited by
ChIP-Seq identification of weakly conserved heart enhancers
Blow, M. J., McCulley, D. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.650 · Cited by 392
Hare, E. E., Peterson, B. K., Iyer, V. N., Meier, R., & Eisen, M. B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000106 · Cited by 302
Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research · doi:10.1101/gr.104471.109 · Cited by 248
Conservation of trans-acting circuitry during mammalian regulatory evolution
Stergachis, A. B., Neph, S., Sandstrom, R., Haugen, E., Reynolds, A. P., Zhang, M., Byron, R., Canfield, T., Stelhing-Sun, S., Lee, K., et al. (2014) · Nature · doi:10.1038/nature13972 · Cited by 212
Ragvin, A., Moro, E., Fredman, D., Navratilova, P., Drivenes, Ø., Engström, P. G., Alonso, M. E., Mustienes, E. D. L. C., Skarmeta, J. L. G., Tavares, M. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911591107 · Cited by 211
Metadata
- Authors
- Fisher, S., Grice, E. A., Vinton, R. M., Bessling, S. L., & McCallion, A. S.
- Venue
- Science
- Published
- 2006-04-14
- Volume
- 312
- Issue
- 5771
- Pages
- 276-279
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966781601
- Cited by
- 354
- References
- 4
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fisher, S., Grice, E. A., Vinton, R. M., Bessling, S. L., & McCallion, A. S. (2006). Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity. Science. https://doi.org/10.1126/science.1124070
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