Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX , SOX4 , and IRX3

Ragvin, Anja; Moro, Enrico; Fredman, David; Navratilova, Pavla; Drivenes, Øyvind; Engström, Pär G.; Alonso, M. Eva; Mustienes, Elisa de la Calle; Skarmeta, José Luis Gómez; Tavares, Maria J.; Casares, Fernando; Manzanares, Miguel; van Heyningen, Veronica; Molven, Anders; Njølstad, Pål R.; Argenton, Francesco; Lenhard, Boris; Becker, Thomas S.

doi:10.1073/pnas.0911591107

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX , SOX4 , and IRX3

Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium (LD) blocks encompassing HHEX-IDE and introns of CDKAL1 and FTO [Sladek R, et al. (2007) Nature 445:881–885; Steinthorsdottir V, et al. (2007) Nat. Genet 39:770–775; Fra…