The DOI matches its Crossref record.
H5N1 Virus Attachment to Lower Respiratory Tract
Abstract
Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached predominantly to type II pneumocytes, alveolar macrophages, and nonciliated bronchiolar cells in the human LRT, and this pattern was most closely mirrored in cat and ferret tissues. These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion.
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Citations
Cited by
Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356
Update on Avian Influenza A (H5N1) Virus Infection in Humans
(2008) · New England Journal of Medicine · doi:10.1056/nejmra0707279 · Cited by 860
Review of Aerosol Transmission of Influenza A virus
Tellier, R. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1211.060426 · Cited by 803
Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00718-9 · Cited by 440
“2a), which is consistent with clinical observations that H5N1 predominantly infects the lower respiratory tract (i.e., rather than the large airway) 23 .”
Glycans on influenza hemagglutinin affect receptor binding and immune response
Wang, C.-C., Chen, J.-R., Tseng, Y.-C., Hsu, C.-H., Hung, Y.-F., Chen, S.-W., Chen, C.-M., Khoo, K.-H., Cheng, T.-J., Cheng, Y.-S. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909696106 · Cited by 316
Metadata
- Authors
- van Riel, D., Munster, V. J., de Wit, E., Rimmelzwaan, G. F., Fouchier, R. A. M., Osterhaus, A. D. M. E., & Kuiken, T.
- Venue
- Science
- Published
- 2006-04-21
- Volume
- 312
- Issue
- 5772
- Pages
- 399-399
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2120113718
- Cited by
- 691
- References
- 0
- FWCI
- 46.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: H5N1 Virus Attachment to Lower Respiratory Tract. https://app.cochat.ai/papers/10.1126/science.1125548
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- van Riel, D., Munster, V. J., de Wit, E., Rimmelzwaan, G. F., Fouchier, R. A. M., Osterhaus, A. D. M. E., & Kuiken, T. (2006). H5N1 Virus Attachment to Lower Respiratory Tract. Science. https://doi.org/10.1126/science.1125548
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
