Update on Avian Influenza A (H5N1) Virus Infection in Humans
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Avian influenza A (H5N1) viruses are entrenched among poultry in parts of Asia and Africa and continue to cause disease with high mortality in humans. This update summarizes recent information including research on the transmission and pathogenesis of the infection and on the current strategies for treatment and prevention. Copyright © 2008 Massachusetts Medical Society. All rights reserved.
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The pathogenic mechanisms of H5N1 may be atypical because the virus is poorly adapted to humans.
“its pathogenic mechanisms may be atypical because the virus is poorly adapted to humans [88]”
From Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness (2008) · cites this paper as [88]
The Viral Factors section (p. 4) says H5N1 does not readily infect humans and that mutations found in some human isolates appear insufficient for efficient human-to-human transmission. The Viral Replication section (p. 4) describes where the virus replicates, but the paper does not say its pathogenic mechanisms are atypical because it is poorly adapted to humans. (LLM, conf=0.83)
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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
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- Authors
- Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus
- Corresponding author
- Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-01-17
- Volume
- 358
- Issue
- 3
- Pages
- 261-273
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1487246189
- Cited by
- 860
- References
- 63
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 8 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 17 · 2019: 21 · 2018: 16 · 2017: 31 · 2016: 33 · 2015: 42 · 2014: 57 · 2013: 65 · 2012: 75
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- H5N1 avian influenza, human infection, poultry, transmission, pathogenesis, antiviral therapy, prevention, mortality
- MeSH terms
- Adult, Age Factors, Animals, Antiviral Agents, Influenza in Birds, Hemagglutinins, Humans, Influenza, Human, Middle Aged, Pneumonia, Viral, Poultry, Virus Replication, Incidence, Influenza A Virus, H5N1 Subtype, Oseltamivir
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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