The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern
Open accessAbstract
Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor ( Mc1r ) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild.
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Cites
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M. (2005) · Science · doi:10.1126/science.1107239 · Cited by 1,448
The Genetic Architecture of Quantitative Traits
Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106
Cited by
Adaptation from standing genetic variation
BARRETT, R., & SCHLUTER, D. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2007.09.008 · Cited by 2,091
Stinchcombe, J. R., & Hoekstra, H. E. (2008) · Heredity · doi:10.1038/sj.hdy.6800937 · Cited by 622
Self-citationComparative studies of gene expression and the evolution of gene regulation
Romero, I. G., Ruvinsky, I., & Gilad, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3229 · Cited by 488
Molecular and Evolutionary History of Melanism in North American Gray Wolves
Anderson, T. M., vonHoldt, B. M., Candille, S. I., Musiani, M., Greco, C., Stahler, D. R., Smith, D. W., Padhukasahasram, B., Randi, E., Leonard, J. A., et al. (2009) · Science · doi:10.1126/science.1165448 · Cited by 416
Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster
Tauber, E., Zordan, M., Sandrelli, F., Pegoraro, M., Osterwalder, N., Breda, C., Daga, A., Selmin, A., Monger, K., Benna, C., et al. (2007) · Science · doi:10.1126/science.1138412 · Cited by 308
Metadata
- Authors
- Hoekstra, H. E., Hirschmann, R. J., Bundey, R. A., Insel, P. A., & Crossland, J. P.
- Venue
- Science
- Published
- 2006-07-07
- Volume
- 313
- Issue
- 5783
- Pages
- 101-104
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062935524
- Cited by
- 716
- References
- 2
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Hoekstra, H. E., Hirschmann, R. J., Bundey, R. A., Insel, P. A., & Crossland, J. P. (2006). A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern. Science. https://doi.org/10.1126/science.1126121
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