Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Abstract
Major phenotypic changes evolve in parallel in nature by molecular mechanisms that are largely unknown. Here, we use positional cloning methods to identify the major chromosome locus controlling armor plate patterning in wild threespine sticklebacks. Mapping, sequencing, and transgenic studies show that the Ectodysplasin (EDA) signaling pathway plays a key role in evolutionary change in natural populations and that parallel evolution of stickleback low-plated phenotypes at most freshwater locations around the world has occurred by repeated selection of Eda alleles derived from an ancestral low-plated haplotype that first appeared more than two million years ago. Members of this clade of low-plated alleles are present at low frequencies in marine fish, which suggests that standing genetic variation can provide a molecular basis for rapid, parallel evolution of dramatic phenotypic change in nature.
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The lack of a coding change at the eda locus in sticklebacks associated with the loss of dermal plates has led to the argument that evolution of this trait is due to changes at cis-regulatory elements controlling eda expression.
“The lack of a coding change at the eda locus in sticklebacks that is associated with the loss of dermal plates has lead to the argument that, in this case, evolution of this trait is due to changes at cis-regulatory elements controlling eda expression [33].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [33]
Evidence from the stickleback suggests that genetic variance at the eda locus underlies differences in the extent of dermal plate formation in diverged populations.
“Additionally, evidence from the stickleback, Gasterosteus aculeatus, suggests that genetic variance at the eda locus underlies differences in the extent of dermal plate formation in diverged populations of this species [33].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [33]
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- Authors
- Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1928-1933
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083653513
- Cited by
- 1,448
- References
- 1
- Citations by year
- 2026: 47 · 2025: 45 · 2024: 58 · 2023: 44 · 2022: 57 · 2021: 67 · 2020: 55 · 2019: 88 · 2018: 74 · 2017: 72 · 2016: 102 · 2015: 85 · 2014: 82 · 2013: 91 · 2012: 88
- FWCI
- 30.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Human Genome Research Institute (P50HG002568)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
- Keywords
- parallel evolution, stickleback, Gasterosteus aculeatus, ectodysplasin, standing genetic variation, allele fixation, freshwater populations, chromosome mapping, transgenic fish
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Cloning, Molecular, Biological Evolution, Fresh Water, Gene Frequency, Haplotypes, Membrane Proteins, Molecular Sequence Data, Mutation, Phenotype, Phylogeny, Seawater, Selection, Genetic, Genetic Variation, Signal Transduction, Linkage Disequilibrium, Chromosome Walking, Sequence Analysis, DNA, Body Patterning, Polymorphism, Single Nucleotide, Smegmamorpha, Animals, Genetically Modified, Ectodysplasins
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