The DOI matches its Crossref record.
Fibrin Fibers Have Extraordinary Extensibility and Elasticity
Open accessAbstract
Blood clots perform an essential mechanical task, yet the mechanical behavior of fibrin fibers, which form the structural framework of a clot, is largely unknown. By using combined atomic force‐fluorescence microscopy, we determined the elastic limit and extensibility of individual fibers. Fibrin fibers can be strained 180% (2.8-fold extension) without sustaining permanent lengthening, and they can be strained up to 525% (average 330%) before rupturing. This is the largest extensibility observed for protein fibers. The data imply that fibrin monomers must be able to undergo sizeable, reversible structural changes and that deformations in clots can be accommodated by individual fiber stretching.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Thrombin generation and fibrin clot structure
Wolberg, A. S. (2007) · Blood Reviews · doi:10.1016/j.blre.2006.11.001 · Cited by 747
Thrombin generation, fibrin clot formation and hemostasis
Wolberg, A. S., & Campbell, R. A. (2008) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2007.12.005 · Cited by 355
Mechanics and contraction dynamics of single platelets and implications for clot stiffening
Lam, W. A., Chaudhuri, O., Crow, A., Webster, K. D., Li, T.-D., Kita, A., Huang, J., & Fletcher, D. A. (2011) · Nature Materials · doi:10.1038/nmat2903 · Cited by 349
Metadata
- Authors
- Liu, W., Jawerth, L. M., Sparks, E. A., Falvo, M. R., Hantgan, R. R., Superfine, R., Lord, S. T., & Guthold, M.
- Venue
- Science
- Published
- 2006-08-04
- Volume
- 313
- Issue
- 5787
- Pages
- 634-634
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2130227698
- Cited by
- 270
- References
- 0
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fibrin Fibers Have Extraordinary Extensibility and Elasticity. https://app.cochat.ai/papers/10.1126/science.1127317
- The paper
- Liu, W., Jawerth, L. M., Sparks, E. A., Falvo, M. R., Hantgan, R. R., Superfine, R., Lord, S. T., & Guthold, M. (2006). Fibrin Fibers Have Extraordinary Extensibility and Elasticity. Science. https://doi.org/10.1126/science.1127317
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
