The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense
Open accessAbstract
The mechanisms underlying induction and suppression of RNA silencing in the ongoing plant-virus arms race are poorly understood. We show here that virus-derived small RNAs produced by Arabidopsis Dicer-like 4 (DCL4) program an effector complex conferring antiviral immunity. Inhibition of DCL4 by a viral-encoded suppressor revealed the subordinate antiviral activity of DCL2. Accordingly, inactivating both DCL2 and DCL4 was necessary and sufficient to restore systemic infection of a suppressor-deficient virus. The effects of DCL2 were overcome by increasing viral dosage in inoculated leaves, but this could not surmount additional, non–cell autonomous effects of DCL4 specifically preventing viral unloading from the vasculature. These findings define a molecular framework for studying antiviral silencing and defense in plants.
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Cited by
Howell, M. D., Fahlgren, N., Chapman, E. J., Cumbie, J. S., Sullivan, C. M., Givan, S. A., Kasschau, K. D., & Carrington, J. C. (2007) · The Plant Cell · doi:10.1105/tpc.107.050062 · Cited by 396
Self-citationSmall RNA Duplexes Function as Mobile Silencing Signals Between Plant Cells
Dunoyer, P., Schott, G., Himber, C., Meyer, D., Takeda, A., Carrington, J. C., & Voinnet, O. (2010) · Science · doi:10.1126/science.1185880 · Cited by 353
Self-citationRetractedThe Ebola Virus VP35 Protein Is a Suppressor of RNA Silencing
Haasnoot, J., de Vries, W., Geutjes, E.-J., Prins, M., de Haan, P., & Berkhout, B. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030086 · Cited by 317
Transposable element small RNAs as regulators of gene expression
McCue, A. D., & Slotkin, R. K. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.09.001 · Cited by 95
Dahal, K., Xia, M., Lu, J., Yan, T., & Lu, R. (2026) · Journal of Virology · doi:10.1128/jvi.01516-25 · Cited by 1
Metadata
- Authors
- Deleris, A., Gallego-Bartolome, J., Bao, J., Kasschau, K. D., Carrington, J. C., & Voinnet, O.
- Venue
- Science
- Published
- 2006-07-07
- Volume
- 313
- Issue
- 5783
- Pages
- 68-71
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150571570
- Cited by
- 933
- References
- 1
- FWCI
- 70.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Deleris, A., Gallego-Bartolome, J., Bao, J., Kasschau, K. D., Carrington, J. C., & Voinnet, O. (2006). Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense. Science. https://doi.org/10.1126/science.1128214
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
