The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Small RNA Duplexes Function as Mobile Silencing Signals Between Plant Cells
Abstract
siRNA Movement in Plant Tissues: Long-distance movement of RNA interference (RNAi)–derived signals in plants plays an important role in development and in defense against viral attack. The nature of the signals that spread from cell to cell is not known, although evidence suggests that they are nucleic acids of some sort (see the Perspective by Martienssen ). Molnar et al. (p. 872 , published online 22 April) and Dunoyer et al. (p. 912 , published online 22 April) now show that in Arabidopsis , both exogenous and endogenous small interfering RNAs (siRNAs), rather than their long double-stranded precursor RNAs, are the molecules that transfer information between plant cells. A viral protein that counters RNAi though sequestering siRNAs blocked spreading of a transgene RNAi silencing signal. Furthermore, siRNA-processing enzymes were required in the source, and not the recipient, cells for spreading, and bombardment of plants with double-stranded siRNAs directly showed siRNA spread between cells. Endogenous siRNAs also spread between tissues and were capable of directing DNA methylation of target sequences in distant tissues.
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Cites
1 retracted
Retracted: An endogenous, systemic RNAi pathway in plants
Dunoyer, P., Brosnan, C. A., Schott, G., Wang, Y., Jay, F., Alioua, A., Himber, C., & Voinnet, O. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.65 · Cited by 235
Self-citationRetractedAsymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922
Baulcombe, D. (2004) · Nature · doi:10.1038/nature02874 · Cited by 2,534
microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants
Allen, E., Xie, Z., Gustafson, A. M., & Carrington, J. C. (2005) · Cell · doi:10.1016/j.cell.2005.04.004 · Cited by 2,268
Self-citationWidespread translational inhibition by plant miRNAs and siRNAs
Brodersen, P., Sakvarelidze-Achard, L., Bruun-Rasmussen, M., Dunoyer, P., Yamamoto, Y. Y., Sieburth, L., & Voinnet, O. (2008) · Science · doi:10.1126/science.1159151 · Cited by 1,477
Self-citationSorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5′ Terminal Nucleotide
Mi, S., Cai, T., Hu, Y., Chen, Y., Hodges, E., Ni, F., Wu, L., Li, S., Zhou, H., Long, C., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.034 · Cited by 1,323
Baumberger, N., & Baulcombe, D. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505461102 · Cited by 1,047
Epigenetic Reprogramming and Small RNA Silencing of Transposable Elements in Pollen
Slotkin, R. K., Vaughn, M., Borges, F., Tanurdžić, M., Becker, J. D., Feijó, J. A., & Martienssen, R. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.038 · Cited by 946
Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense
Deleris, A., Gallego-Bartolome, J., Bao, J., Kasschau, K. D., Carrington, J. C., & Voinnet, O. (2006) · Science · doi:10.1126/science.1128214 · Cited by 933
Self-citationMontgomery, T. A., Howell, M. D., Cuperus, J. T., Li, D., Hansen, J. E., Alexander, A. L., Chapman, E. J., Fahlgren, N., Allen, E., & Carrington, J. C. (2008) · Cell · doi:10.1016/j.cell.2008.02.033 · Cited by 774
Self-citation
Cited by
An epigenetic view of plant cells cultured in vitro: Somaclonal variation and beyond
Miguel, C., & Marum, L. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err155 · Cited by 395
Metadata
- Authors
- Dunoyer, P., Schott, G., Himber, C., Meyer, D., Takeda, A., Carrington, J. C., & Voinnet, O.
- Venue
- Science
- Published
- 2010-05-14
- Volume
- 328
- Issue
- 5980
- Pages
- 912-916
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060797201
- Cited by
- 353
- References
- 20
- FWCI
- 72.76
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Dunoyer, P., Schott, G., Himber, C., Meyer, D., Takeda, A., Carrington, J. C., & Voinnet, O. (2010). Small RNA Duplexes Function as Mobile Silencing Signals Between Plant Cells. Science. https://doi.org/10.1126/science.1185880
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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