The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in Salmonella
Abstract
Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired sequences can decrease fitness unless integrated into preexisting regulatory networks. We found that the histone-like nucleoid structuring protein (H-NS) selectively silences horizontally acquired genes by targeting sequences with GC content lower than the resident genome. Mutations in hns are lethal in Salmonella unless accompanied by compensatory mutations in other regulatory loci. Thus, H-NS provides a previously unrecognized mechanism of bacterial defense against foreign DNA, enabling the acquisition of DNA from exogenous sources while avoiding detrimental consequences from unregulated expression of newly acquired genes. Characteristic GC/AT ratios of bacterial genomes may facilitate discrimination between a cell's own DNA and foreign DNA.
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Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
McClelland, M., Sanderson, K. E., Spieth, J., Clifton, S. W., Latreille, P., Courtney, L., Porwollik, S., Ali, J., Dante, M., Du, F., et al. (2001) · Nature · doi:10.1038/35101614 · Cited by 1,837
Self-citationH-NS: a universal regulator for a dynamic genome
Dorman, C. J. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro883 · Cited by 578
Transcriptional silencing and thermoregulation of gene expression in Escherichia coli
Göransson, M., Sondén, B., Nilsson, P., Dagberg, B., Foreman, K., Emanuelsson, K., & Uhlin, B. E. (1990) · Nature · doi:10.1038/344682a0 · Cited by 310
The chromatin-associated protein H-NS alters DNA topology in vitro.
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Increased Bending Rigidity of Single DNA Molecules by H-NS, a Temperature and Osmolarity Sensor
Amit, R., Oppenheim, A. B., & Stavans, J. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75051-6 · Cited by 194
Hardy, C. D., & Cozzarelli, N. R. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04799.x · Cited by 171
DNA Bridging: a Property Shared among H-NS-Like Proteins
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What is driving the acquisition of mutS and rpoS polymorphisms in Escherichia coli?
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Bacterial Stress Responses during Host Infection
Fang, F. C., Frawley, E. R., Tapscott, T., & Vázquez-Torres, A. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.009 · Cited by 319
Self-citationMechanisms of Gold Bioaccumulation by Filamentous Cyanobacteria from Gold(III)−Chloride Complex
Lengke, M. F., Ravel, B., Fleet, M. E., Wanger, G., Gordon, R. A., & Southam, G. (2006) · Environmental Science & Technology · doi:10.1021/es061040r · Cited by 314
Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome
Ilyas, B., Tsai, C. N., & Coombes, B. K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00428 · Cited by 128
Barquist, L., Langridge, G. C., Turner, D. J., Phan, M.-D., Turner, A. K., Bateman, A., Parkhill, J., Wain, J., & Gardner, P. P. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt148 · Cited by 121
Metadata
- Authors
- Navarre, W. W., Porwollik, S., Wang, Y., McClelland, M., Rosen, H., Libby, S. J., & Fang, F. C.
- Venue
- Science
- Published
- 2006-07-14
- Volume
- 313
- Issue
- 5784
- Pages
- 236-238
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2160174395
- Cited by
- 722
- References
- 17
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Navarre, W. W., Porwollik, S., Wang, Y., McClelland, M., Rosen, H., Libby, S. J., & Fang, F. C. (2006). Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in Salmonella. Science. https://doi.org/10.1126/science.1128794
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