CRISPR-mediated adaptive immune systems in bacteria and archaea

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 6,304 · see citing works

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

Brouns, S. J. J., Jore, M. M., Lundgren, M., Westra, E. R., Slijkhuis, R. J. H., Snijders, A. P., Dickman, M. J., Makarova, K. S., Koonin, E. V., & John van der, O. O. S. T. (2008) · Science · doi:10.1126/science.1159689 · Cited by 2,593 · see citing works

CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III

Deltcheva, E., Chylinski, K., Sharma, C. M., Gonzales, K., Chao, Y., Pirzada, Z. A., Eckert, M. R., Vogel, J., & Charpentier, E. (2011) · Nature · doi:10.1038/nature09886 · Cited by 2,563 · see citing works

Evolution and classification of the CRISPR–Cas systems

Makarova, K. S., Haft, D. H., Barrangou, R., Brouns, S. J. J., Charpentier, E., Horvath, P., Moineau, S., Mojica, F. J. M., Wolf, Y. I., Yakunin, A. F., et al. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2577 · Cited by 2,512 · see citing works

CRISPR/Cas, the Immune System of Bacteria and Archaea

Horvath, P., & Barrangou, R. (2010) · Science · doi:10.1126/science.1179555 · Cited by 2,471 · see citing works

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

Garneau, J. E., Dupuis, M.-È., Villion, M., Romero, D. A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A. H., & Moineau, S. (2010) · Nature · doi:10.1038/nature09523 · Cited by 2,336 · see citing works

Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

Mojica, F. J. M., D�ez-Villase�or, C., Garc�a-Mart�nez, J., & Soria, E. (2005) · Journal of Molecular Evolution · doi:10.1007/s00239-004-0046-3 · Cited by 2,219 · see citing works

Viruses in the sea

Suttle, C. A. (2005) · Nature · doi:10.1038/nature04160 · Cited by 2,186 · see citing works

Identification of genes that are associated with DNA repeats in prokaryotes

Jansen, R., van Embden, J. D. A., Gaastra, W., & Schouls, L. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02839.x · Cited by 2,035 · see citing works

CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats

Grissa, I., Vergnaud, G., & Pourcel, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm360 · Cited by 1,877 · see citing works

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature · doi:10.1038/nature10886 · Cited by 1,851 · see citing works

Ecology of prokaryotic viruses

Weinbauer, M. G. (2003) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2003.08.001 · Cited by 1,776 · see citing works

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

Marraffini, L. A., & Sontheimer, E. J. (2008) · Science · doi:10.1126/science.1165771 · Cited by 1,752 · see citing works

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

Bolotin, A., Quinquis, B., Sorokin, A., & Ehrlich, S. D. (2005) · Microbiology · doi:10.1099/mic.0.28048-0 · Cited by 1,733 · see citing works

High abundance of viruses found in aquatic environments

Bergh, Ø., Børsheim, K. Y., Bratbak, G., & Heldal, M. (1989) · Nature · doi:10.1038/340467a0 · Cited by 1,650 · see citing works

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

Mojica, F. J. M., Díez‐Villaseñor, C., García‐Martínez, J., & Almendros, C. (2009) · Microbiology · doi:10.1099/mic.0.023960-0 · Cited by 1,500 · see citing works

CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies

Pourcel, C., Salvignol, G., & Vergnaud, G. (2005) · Microbiology · doi:10.1099/mic.0.27437-0 · Cited by 1,347 · see citing works

A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

Makarova, K. S., Grishin, N. V., Shabalina, S. A., Wolf, Y. I., & Koonin, E. V. (2006) · Biology Direct · doi:10.1186/1745-6150-1-7 · Cited by 1,199 · see citing works

Phage Response to CRISPR-Encoded Resistance in Streptococcus thermophilus

Deveau, H., Barrangou, R., Garneau, J. E., Labonté, J., Fremaux, C., Boyaval, P., Romero, D. A., Horvath, P., & Moineau, S. (2007) · Journal of Bacteriology · doi:10.1128/jb.01412-07 · Cited by 1,196 · see citing works

(p)ppGpp: Still Magical?

Potrykus, K., & Cashel, M. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.162903 · Cited by 1,170 · see citing works

The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression

Maris, C., Dominguez, C., & Allain, F. H. ‐. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04653.x · Cited by 1,135 · see citing works

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

Hale, C. R., Zhao, P., Olson, S., Duff, M. O., Graveley, B. R., Wells, L., Terns, R. M., & Terns, M. P. (2009) · Cell · doi:10.1016/j.cell.2009.07.040 · Cited by 1,031 · see citing works

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

Marraffini, L. A., & Sontheimer, E. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2749 · Cited by 1,011 · see citing works

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Haft, D. H., Selengut, J., Mongodin, E. F., & Nelson, K. E. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010060 · Cited by 981 · see citing works

The human gut virome: inter-individual variation and dynamic response to diet

Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S. A., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2011) · Genome Research · doi:10.1101/gr.122705.111 · Cited by 935 · see citing works

How do site-specific DNA-binding proteins find their targets?

Halford, S. E. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh624 · Cited by 891 · see citing works

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

Sebaihia, M., Wren, B. W., Mullany, P. P., Fairweather, N. F., Minton, N. P., Stabler, R. A., Thomson, N. R., Roberts, A. P., Cerdeño-Tárraga, A. M., Wang, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1830 · Cited by 877 · see citing works

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

Sapranauskas, R., Gasiūnas, G., Fremaux, C., Barrangou, R., Horvath, P., & Šikšnys, V. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr606 · Cited by 835 · see citing works

Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria

Mojica, F. J. M., Díez‐Villaseñor, C., Soria, E., & Juez, G. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01838.x · Cited by 821 · see citing works

Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus

Horvath, P., Romero, D. A., Coûté-Monvoisin, A.-C., Richards, M., Deveau, H., Moineau, S., Boyaval, P., Fremaux, C., & Barrangou, R. (2007) · Journal of Bacteriology · doi:10.1128/jb.01415-07 · Cited by 775 · see citing works

Arginine-Mediated RNA Recognition: the Arginine Fork

Calnan, B. J., Tidor, B., Biancalana, S., Hudson, D., & Frankel, A. D. (1991) · Science · doi:10.1126/science.252.5009.1167 · Cited by 746 · see citing works

Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in Salmonella

Navarre, W. W., Porwollik, S., Wang, Y., McClelland, M., Rosen, H., Libby, S. J., & Fang, F. C. (2006) · Science · doi:10.1126/science.1128794 · Cited by 727 · see citing works

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

Semenova, E., Jore, M. M., Datsenko, K. A., Semenova, A., Westra, E. R., Wanner, B. L., John van der, O. O. S. T., Brouns, S. J. J., & Severinov, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104144108 · Cited by 726 · see citing works

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

Chen, Z., Yang, H., & Pavletich, N. P. (2008) · Nature · doi:10.1038/nature06971 · Cited by 720 · see citing works

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

Haurwitz, R. E., Jínek, M., Wiedenheft, B., Zhou, K., & Doudna, J. A. (2010) · Science · doi:10.1126/science.1192272 · Cited by 710 · see citing works

Nucleases: diversity of structure, function and mechanism

Yang, W. (2011) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000181 · Cited by 692 · see citing works

Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli

Yosef, I., Goren, M. G., & Qimron, U. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks216 · Cited by 680 · see citing works

Explaining Microbial Population Genomics through Phage Predation

Rodriguez-Valera, F., Martin-Cuadrado, A.-B., Rodriguez-Brito, B., Pašić, L., Thingstad, T. F., Rohwer, F., & Mira, A. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2235 · Cited by 663 · see citing works

Self versus non-self discrimination during CRISPR RNA-directed immunity

Marraffini, L. A., & Sontheimer, E. J. (2010) · Nature · doi:10.1038/nature08703 · Cited by 642 · see citing works

Metagenomics: DNA sequencing of environmental samples

Green, S., & Rubin, E. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1709 · Cited by 631 · see citing works

CRISPR/Cas System and Its Role in Phage-Bacteria Interactions

Deveau, H., Garneau, J. E., & Moineau, S. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134123 · Cited by 624 · see citing works

Bacteriophages: Biology and Applications

Silver, S. D., & Baylor, M. B. (2006) · Microbe Magazine · doi:10.1128/microbe.1.151.1 · Cited by 576 · see citing works

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

Datsenko, K. A., Pougach, K., Tikhonov, A., Wanner, B. L., Severinov, K., & Semenova, E. (2012) · Nature Communications · doi:10.1038/ncomms1937 · Cited by 569 · see citing works

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

Jore, M. M., Lundgren, M., van Duijn, E., Bultema, J. B., Westra, E. R., Waghmare, S. P., Wiedenheft, B., Pul, Ü., Wurm, R., Wagner, R., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2019 · Cited by 557 · see citing works

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotesPreprint

Carte, J. M., Wang, R., Li, H., Terns, R. M., & Terns, M. P. (2008) · Genes & Development · doi:10.1101/gad.1742908 · Cited by 551 · see citing works

The phage‐host arms race: Shaping the evolution of microbes

Stern, A., & Sorek, R. (2010) · BioEssays · doi:10.1002/bies.201000071 · Cited by 527 · see citing works

CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3

Westra, E. R., van Erp, P. B. G., Künne, T., Wong, S. P., Staals, R. H. J., Seegers, C. L. C., Bollen, S., Jore, M. M., Semenova, E., Severinov, K., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.018 · Cited by 511 · see citing works

Phage as agents of lateral gene transfer

Canchaya, C. A., Fournous, G., Chibani-Chennoufi, S., Dillmann, M.-L., & Brüssow, H. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00086-9 · Cited by 503 · see citing works

Bacteria-Phage Antagonistic Coevolution in Soil

Gómez, P., & Buckling, A. G. J. (2011) · Science · doi:10.1126/science.1198767 · Cited by 492 · see citing works

Virus Population Dynamics and Acquired Virus Resistance in Natural Microbial Communities

Andersson, A. F., & Banfield, J. F. (2008) · Science · doi:10.1126/science.1157358 · Cited by 486 · see citing works

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

Wiedenheft, B., van Duijn, E., Bultema, J. B., Waghmare, S. P., Zhou, K., Barendregt, A., Westphal, W., Heck, A. J. R., Boekema, E. J., Dickman, M. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102716108 · Cited by 449 · see citing works

Evolutionary conservation of sequence and secondary structures in CRISPR repeats

Kunin, V., Sorek, R., & Hugenholtz, P. (2007) · Genome biology · doi:10.1186/gb-2007-8-4-r61 · Cited by 449 · see citing works

Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system

Šinkūnas, T., Gasiūnas, G., Fremaux, C., Barrangou, R., Horvath, P., & Šikšnys, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.41 · Cited by 441 · see citing works

Multidrug-Resistant Enterococci Lack CRISPR- cas

Palmer, K. L., & Gilmore, M. S. (2010) · mBio · doi:10.1128/mbio.00227-10 · Cited by 441 · see citing works

Structures of the RNA-guided surveillance complex from a bacterial immune system

Wiedenheft, B., Lander, G. C., Zhou, K., Jore, M. M., Brouns, S. J. J., John van der, O. O. S. T., Doudna, J. A., & Nogales, E. (2011) · Nature · doi:10.1038/nature10402 · Cited by 398 · see citing works

Self-targeting by CRISPR: gene regulation or autoimmunity?

Stern, A., Keren, L., Wurtzel, O., Amitai, G., & Sorek, R. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.05.008 · Cited by 384 · see citing works

CRISPR Interference Directs Strand Specific Spacer Acquisition

Swarts, D. C., Mosterd, C., van Passel, M. W. J., & Brouns, S. J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035888 · Cited by 378 · see citing works

A single-base resolution map of an archaeal transcriptomePreprint

Wurtzel, O., Sapra, R., Chen, F., Zhu, Y., Simmons, B. A., & Sorek, R. (2009) · Genome Research · doi:10.1101/gr.100396.109 · Cited by 356 · see citing works

The Repetitive DNA Elements Called CRISPRs and Their Associated Genes: Evidence of Horizontal Transfer Among Prokaryotes

Godde, J. S., & Bickerton, A. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0223-z · Cited by 339 · see citing works

Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus

Tang, T., Bachellerie, J., Rozhdestvensky, T. S., Bortolin‐Cavaillé, M., Huber, H., Drungowski, M., Elge, T., Brosius, J., & Hüttenhofer, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112047299 · Cited by 337 · see citing works

Rapidly evolving CRISPRs implicated in acquired resistance of microorganisms to viruses

Tyson, G. W., & Banfield, J. F. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01444.x · Cited by 321 · see citing works

Silencing of xenogeneic DNA by H-NS—facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNAPreprint

Navarre, W. W., McClelland, M., Libby, S. J., & Fang, F. C. (2007) · Genes & Development · doi:10.1101/gad.1543107 · Cited by 310 · see citing works

Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

Makarova, K. S., Wolf, Y. I., John van der, O. O. S. T., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-29 · Cited by 305 · see citing works

Genomic island variability facilitates Prochlorococcus–virus coexistence

Avrani, S., Wurtzel, O., Sharon, I., Sorek, R., & Lindell, D. (2011) · Nature · doi:10.1038/nature10172 · Cited by 304 · see citing works

Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs

Hale, C. R., Majumdar, S., Elmore, J. R., Pfister, N. T., Compton, M. M., Olson, S., Resch, A. M., Glover, C. V. C., Graveley, B. R., Terns, R. M., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.10.023 · Cited by 294 · see citing works

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

Zhang, J., Rouillon, C., Kerou, M., Reeks, J., Brügger, K., Graham, S., Reimann, J., Cannone, G., Liu, H., Albers, S., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.013 · Cited by 292 · see citing works

Identification and characterization of E. coli CRISPR‐cas promoters and their silencing by H‐NS

Pul, Ü., Wurm, R., Arslan, Z., Geißen, R., Hofmann, N., & Wagner, R. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07073.x · Cited by 286 · see citing works

The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity

Westra, E. R., Swarts, D. C., Staals, R. H. J., Jore, M. M., Brouns, S. J. J., & John van der, O. O. S. T. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155447 · Cited by 278 · see citing works

The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages

Cady, K. C., Bondy-Denomy, J., Heussler, G. E., Davidson, A. R., & O’Toole, G. A. (2012) · Journal of Bacteriology · doi:10.1128/jb.01184-12 · Cited by 274 · see citing works

High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes

Lang, B., Blot, N., Bouffartigues, E., Buckle, M., Geertz, M., Gualerzi, C. O., Mavathur, R. N., Muskhelishvili, G., Pon, C. L., Rimsky, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm712 · Cited by 269 · see citing works

A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair

Babu, M., Beloglazova, N. G., Flick, R., Graham, C., Skarina, T., Nocek, B. P., Gagarinova, A. G., Pogoutse, O., Brown, G., Binkowski, A., et al. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07465.x · Cited by 260 · see citing works

Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense

Wiedenheft, B., Zhou, K., Jínek, M., Coyle, S. M., Ma, W., & Doudna, J. A. (2009) · Structure · doi:10.1016/j.str.2009.03.019 · Cited by 256 · see citing works

H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencing

Bouffartigues, E., Buckle, M., Badaut, C., TRAVERS, A. A., & Rimsky, S. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1233 · Cited by 251 · see citing works

H‐NS‐mediated repression of CRISPR‐based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO

Westra, E. R., Pul, Ü., Heidrich, N., Jore, M. M., Lundgren, M., Stratmann, T., Wurm, R., Raine, A., Mescher, M., van Heereveld, L., et al. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07315.x · Cited by 243 · see citing works

Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

Sashital, D. G., Wiedenheft, B., & Doudna, J. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.020 · Cited by 238 · see citing works

Prokaryotic silencing (psi)RNAs inPyrococcus furiosus

Hale, C. R., Kleppe, K. L., Terns, R. M., & Terns, M. P. (2008) · RNA · doi:10.1261/rna.1246808 · Cited by 230 · see citing works

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modesPreprint

Liu, Y., Chen, H., Kenney, L. J., & Yan, J. (2010) · Genes & Development · doi:10.1101/gad.1883510 · Cited by 229 · see citing works

Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector‐borne viral and plasmid genes and protospacers

Gudbergsdóttir, S. R., Deng, L., Chen, Z., Jensen, J. V. K., Jensen, L. R., She, Q., & Garrett, R. A. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07452.x · Cited by 228 · see citing works

Transcription, processing and function of CRISPR cassettes in Escherichia coli

Pougach, K., Semenova, E., Bogdanova, E. S., Datsenko, K. A., Djordjević, M., Wanner, B. L., & Severinov, K. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07265.x · Cited by 228 · see citing works

CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties

Lillestøl, R., Shah, S. A., Brügger, K., Redder, P., Phan, H., Christiansen, J., & Garrett, R. A. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06641.x · Cited by 215 · see citing works

CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiomePreprint

Stern, A., Mick, E., Tirosh, I., Sagy, O., & Sorek, R. (2012) · Genome Research · doi:10.1101/gr.138297.112 · Cited by 212 · see citing works

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

Nam, K. H., Haitjema, C. H., Liu, X., Ding, F., Wang, H., DeLisa, M. P., & Ke, A. (2012) · Structure · doi:10.1016/j.str.2012.06.016 · Cited by 210 · see citing works

Identification of novel non‐coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus

Tang, T., Polacek, N., Żywicki, M., Huber, H., Brügger, K., Garrett, R. A., Bachellerie, J., & Hüttenhofer, A. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04428.x · Cited by 210 · see citing works

Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)

Lintner, N. G., Kerou, M., Brumfield, S. K., Graham, S., Liu, H., Naismith, J. H., Sdano, M. A., Peng, N., She, Q., Copié, V., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238485 · Cited by 201 · see citing works

A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats

Beloglazova, N. G., Brown, G., Zimmerman, M. D., Proudfoot, M., Makarova, K. S., Kudritska, M., Kochinyan, S., Wang, S., Chruszcz, M., Minor, W., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803225200 · Cited by 200 · see citing works

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