The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion
Open accessAbstract
Assembly of the soluble N -ethylmaleimide–sensitive factor attachment protein receptors (SNAREs) syntaxin 1, SNAP-25, and synaptobrevin 2 is thought to be the driving force for the exocytosis of synaptic vesicles. However, whereas exocytosis is triggered at a millisecond time scale, the SNARE-mediated fusion of liposomes requires hours for completion, which challenges the idea of a key role for SNAREs in the final steps of exocytosis. We found that liposome fusion was dramatically accelerated when a stabilized syntaxin/SNAP-25 acceptor complex was used. Thus, SNAREs do have the capacity to execute fusion at a speed required for neuronal secretion, demonstrating that the maintenance of acceptor complexes is a critical step in biological fusion reactions.
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Cites
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Self-citationTiming of neurotransmission at fast synapses in the mammalian brain
Sabatini, B. L., & Regehr, W. G. (1996) · Nature · doi:10.1038/384170a0 · Cited by 442
Cited by
Mechanisms of membrane fusion: disparate players and common principles
Martens, S., & McMahon, H. T. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2417 · Cited by 710
Rizo, J., & Rosenmund, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1450 · Cited by 538
Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release
Kaeser, P. S., & Regehr, W. G. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170338 · Cited by 447
Membrane Fusion Intermediates via Directional and Full Assembly of the SNARE Complex
Hernandez, J. M., Stein, A., Behrmann, E., Riedel, D., Cypionka, A., Farsi, Z., Walla, P. J., Raunser, S., & Jahn, R. (2012) · Science · doi:10.1126/science.1221976 · Cited by 256
Self-citationMechanisms of SNARE proteins in membrane fusion
Jahn, R., Cafiso, D. C., & Tamm, L. K. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00668-x · Cited by 248
Metadata
- Authors
- Pobbati, A. V., Stein, A., & Fasshauer, D.
- Venue
- Science
- Published
- 2006-08-04
- Volume
- 313
- Issue
- 5787
- Pages
- 673-676
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974537340
- Cited by
- 394
- References
- 3
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- green
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