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Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids
Abstract
The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as “eat me” signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.
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Citations
Cited by
Cowman, A. F., Healer, J., Marapana, D., & Marsh, K. (2016) · Cell · doi:10.1016/j.cell.2016.07.055 · Cited by 890
Malaria: progress, perils, and prospects for eradication
Greenwood, B. M., Fidock, D. A., Kyle, D. E., Kappe, S. H. I., Alonso, P. L., Collins, F. H., & Duffy, P. E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33996 · Cited by 709
Living in the liver: hepatic infections
Protzer, U., Maini, M. K., & Knolle, P. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3169 · Cited by 560
Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology
Sato, S. (2021) · Journal of Physiological Anthropology · doi:10.1186/s40101-020-00251-9 · Cited by 404
Tuteja, R. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05997.x · Cited by 302
Metadata
- Authors
- Sturm, A., Amino, R., van de Sand, C., Regen, T., Retzlaff, S., Rennenberg, A., Krueger, A., Pollok, J.-M., Menard, R., & Heussler, V. T.
- Venue
- Science
- Published
- 2006-09
- Volume
- 313
- Issue
- 5791
- Pages
- 1287-1290
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990402424
- Cited by
- 589
- References
- 0
- FWCI
- 30.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids. https://app.cochat.ai/papers/10.1126/science.1129720
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- Sturm, A., Amino, R., van de Sand, C., Regen, T., Retzlaff, S., Rennenberg, A., Krueger, A., Pollok, J.-M., Menard, R., & Heussler, V. T. (2006). Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids. Science. https://doi.org/10.1126/science.1129720
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
