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An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides That Target Lipid II
Open accessAbstract
Lantibiotics are polycyclic peptides containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and thereby lyse the cells. Yet several members of these lipid II–targeted lantibiotics are too short to be able to span the lipid bilayer and cannot form pores, but somehow they maintain their antibacterial efficacy. We describe an alternative mechanism by which members of the lantibiotic family kill Gram-positive bacteria by removing lipid II from the cell division site (or septum) and thus block cell wall synthesis.
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Gray, K. C., Palacios, D. S., Dailey, I., Endo, M. M., Uno, B. E., Wilcock, B. C., & Burke, M. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117280109 · Cited by 608
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Chikindas, M. L., Weeks, R., Drider, D., Chistyakov, V. A., & Dicks, L. M. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.07.011 · Cited by 574
Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection
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Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations
Soltani, S., Hammami, R., Cotter, P. D., Rebuffat, S., Said, L. B., Gaudreau, H., Bédard, F., Biron, E., Drider, D., & Fliss, I. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa039 · Cited by 544
Metadata
- Authors
- Hasper, H. E., Kramer, N. E., Smith, J. L., Hillman, J. D., Zachariah, C., Kuipers, O. P., de Kruijff, B., & Breukink, E.
- Venue
- Science
- Published
- 2006-09-15
- Volume
- 313
- Issue
- 5793
- Pages
- 1636-1637
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073097129
- Cited by
- 501
- References
- 0
- FWCI
- 21.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Hasper, H. E., Kramer, N. E., Smith, J. L., Hillman, J. D., Zachariah, C., Kuipers, O. P., de Kruijff, B., & Breukink, E. (2006). An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides That Target Lipid II. Science. https://doi.org/10.1126/science.1129818
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