Cited by 576Gut microbiota and healthClostridium difficile and Clostridium perfringens researchProbiotics and Fermented Foods

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection

Open access
Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., Kuijper, E. J.·2019·Microbiology and Molecular Biology Reviews

Abstract

The gut microbiome is critical in providing resistance against colonization by exogenous microorganisms. The mechanisms via which the gut microbiota provide colonization resistance (CR) have not been fully elucidated, but they include secretion of antimicrobial products, nutrient competition, support of gut barrier integrity, and bacteriophage deployment.

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Crossref · 10.1128/mmbr.00007-19

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286 of 286 references verified0 citation errors · 0 not checkable

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  • The gut microbiota protects against intestinal colonization by pathogens via colonization resistance through both direct and indirect mechanisms.

    “The gut microbiota protects against intestinal colonization by pathogens via colonization resistance through both direct and indirect mechanisms.”
  • Examples of direct mechanisms of colonization resistance include nutrient competition between gut commensals and pathogens, production of inhibitory metabolites by gut commensals, production of bacteriocins by gut commensals, and the presence of bacteriophages.

    “Examples of direct mechanisms of colonization resistance include nutrient competition between gut commensals and pathogens, production of inhibitory metabolites by gut commensals, production of bacteriocins by gut commensals, and the presence of bacteriophages [33, 34].”

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Cites

1 retracted

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2 of the 288 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. 10.1038/s41586-019-0965 · DOI
  2. Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM. 1999. Global burden of Shigella infections implications for vaccine development. Bull World Health Organ 77:651–666.

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Authors
Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., & Kuijper, E. J.
Affiliations
  • Leiden University Medical Center (NL)
  • Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
  • University of Michigan (US)
Venue
Microbiology and Molecular Biology Reviews
Published
2019-08-21
Volume
83
Issue
3
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
OpenAlex
W2948451181
Cited by
566
References
288
Citations by year
2026: 81 · 2025: 86 · 2024: 109 · 2023: 99 · 2022: 71 · 2021: 67 · 2020: 48 · 2019: 4
FWCI
4.18
Type
journal article
Language
en
Open access
Locations
  • Microbiology and Molecular Biology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Funders
  • Royal Society Wolfson Research Merit Award (WM160092)
  • Vedanta Biosciences Inc. (Unrestricted)
  • HHS | National Institutes of Health (AI124255)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, colonization resistance, enteric bacterial infection, antimicrobial peptides, nutrient competition, intestinal barrier integrity, bacteriophages, host-microbe interactions
MeSH terms
Gastrointestinal Microbiome, Animals, Anti-Infective Agents, Bacteria, Bacterial Infections, Fatty Acids, Volatile, Humans, Mucus, Mice

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