Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection
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The gut microbiome is critical in providing resistance against colonization by exogenous microorganisms. The mechanisms via which the gut microbiota provide colonization resistance (CR) have not been fully elucidated, but they include secretion of antimicrobial products, nutrient competition, support of gut barrier integrity, and bacteriophage deployment.
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The gut microbiota protects against intestinal colonization by pathogens via colonization resistance through both direct and indirect mechanisms.
“The gut microbiota protects against intestinal colonization by pathogens via colonization resistance through both direct and indirect mechanisms.”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [33]
Examples of direct mechanisms of colonization resistance include nutrient competition between gut commensals and pathogens, production of inhibitory metabolites by gut commensals, production of bacteriocins by gut commensals, and the presence of bacteriophages.
“Examples of direct mechanisms of colonization resistance include nutrient competition between gut commensals and pathogens, production of inhibitory metabolites by gut commensals, production of bacteriocins by gut commensals, and the presence of bacteriophages [33, 34].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [33]
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Consideration of Gut Microbiome in Murine Models of Diseases
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A Review of the Mechanisms of Bacterial Colonization of the Mammal Gut
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- Authors
- Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., & Kuijper, E. J.
- Affiliations
- Leiden University Medical Center (NL)
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- University of Michigan (US)
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2019-08-21
- Volume
- 83
- Issue
- 3
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC6710460
- OpenAlex
- W2948451181
- Cited by
- 566
- References
- 288
- Citations by year
- 2026: 81 · 2025: 86 · 2024: 109 · 2023: 99 · 2022: 71 · 2021: 67 · 2020: 48 · 2019: 4
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Royal Society Wolfson Research Merit Award (WM160092)
- Vedanta Biosciences Inc. (Unrestricted)
- HHS | National Institutes of Health (AI124255)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, colonization resistance, enteric bacterial infection, antimicrobial peptides, nutrient competition, intestinal barrier integrity, bacteriophages, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anti-Infective Agents, Bacteria, Bacterial Infections, Fatty Acids, Volatile, Humans, Mucus, Mice
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