The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Dual Infection with HIV and Malaria Fuels the Spread of Both Diseases in Sub-Saharan Africa
Abstract
Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of the interplay have remained unclear. A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes; in addition, susceptibility to malaria is enhanced in HIV-infected patients. A mathematical model applied to a setting in Kenya with an adult population of roughly 200,000 estimated that, since 1980, the disease interaction may have been responsible for 8,500 excess HIV infections and 980,000 excess malaria episodes. Co-infection might also have facilitated the geographic expansion of malaria in areas where HIV prevalence is high. Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa.
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Cites
Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
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Cited by
Global malaria mortality between 1980 and 2010: a systematic analysis
Murray, C. J., Rosenfeld, L. C., Lim, S. S., Andrews, K. G., Foreman, K. J., Haring, D., Fullman, N., Naghavi, M., Lozano, R., & Lopez, A. D. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60034-8 · Cited by 1,452
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(2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12313_2 · Cited by 543
Estimating the Global Clinical Burden of Plasmodium falciparum Malaria in 2007
Hay, S. I., Okiro, E. A., Gething, P. W., Patil, A. P., Tatem, A. J., Guerra, C. A., & Snow, R. W. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000290 · Cited by 374
Metadata
- Authors
- Abu-Raddad, L. J., Patnaik, P., & Kublin, J. G.
- Venue
- Science
- Published
- 2006-12-08
- Volume
- 314
- Issue
- 5805
- Pages
- 1603-1606
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994333367
- Cited by
- 484
- References
- 23
- FWCI
- 26.41
- Type
- journal article
- Language
- en
- Open access
- closed
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