The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
100 Years and Counting: Prospects for Defeating Alzheimer's Disease
Open accessAbstract
This week marks a century since the first description of Alzheimer's disease (AD). Despite approval of several drugs for AD, the disease continues to rob millions of their memories and their lives. Fortunately, many new therapies directly targeting the mechanisms underlying AD are now in the pipeline. Among the investigative AD therapies in clinical trials are several strategies to block pathogenic amyloid-β peptides and to rescue vulnerable neurons from degeneration. Complementary but less mature strategies aim to prevent the copathogenic effects of apolipoprotein E and the microtubule-associated protein tau. New insights into selective neuronal vulnerability and the link between aging and AD may provide additional entry points for therapeutic interventions. The predicted increase in AD cases over the next few decades makes the development of better treatments a matter of utmost importance and urgency.
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Cited by
Forecasting the global burden of Alzheimer's disease
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The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives
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Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
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Evidence for natural antisense transcript-mediated inhibition of microRNA function
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Metadata
- Authors
- Roberson, E. D., & Mucke, L.
- Venue
- Science
- Published
- 2006-11-03
- Volume
- 314
- Issue
- 5800
- Pages
- 781-784
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054648295
- Cited by
- 550
- References
- 23
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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