A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works

The cholinergic hypothesis of geriatric memory dysfunction

Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works

A new rating scale for Alzheimer's disease

(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175 · see citing works

The Nerve Growth Factor 35 Years Later

Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109 · see citing works

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043 · see citing works

Regulation of Cell Survival by Secreted Proneurotrophins

Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,455 · see citing works

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290 · see citing works

Cortical Map Reorganization Enabled by Nucleus Basalis Activity

Kilgard, M. P., & Merzenich, M. M. (1998) · Science · doi:10.1126/science.279.5357.1714 · Cited by 1,197 · see citing works

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024 · see citing works

Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

Selkoe, D. J., & Schenk, D. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 816 · see citing works

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase

Mesulam, M. M., & Geula, C. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902750205 · Cited by 520 · see citing works

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

Rosenberg, M. B., Friedmann, T., Robertson, R., Tuszynski, M. H., Wolff, J. A., Breakefield, X. O., & Gage, F. H. (1988) · Science · doi:10.1126/science.3201248 · Cited by 505 · see citing works

Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line—derived neurotrophic factor

Slevin, J. T., Gerhardt, G. A., Smith, C. D., Gash, D. M., Kryscio, R. J., & Young, B. A. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.102.2.0216 · Cited by 474 · see citing works

Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease

Jönhagen, M. E., Nordberg, A. K., Amberla, K., Bäckman, L., Ebendal, T., Meyerson, B. A., Olson, L., Seiger, Å., Shigeta, M., Theodorsson, E., et al. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017069 · Cited by 472 · see citing works

The Cholinergic Lesion of Alzheimer's Disease: Pivotal Factor or Side Show?

Mesulam, M. (2004) · Learning & Memory · doi:10.1101/lm.69204 · Cited by 467 · see citing works

A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration

(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.3.390 · Cited by 408 · see citing works

Treatment of Alzheimer's Disease

Mayeux, R. P., & Sano, M. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911253412207 · Cited by 388 · see citing works

Synaptic and neuritic alterations during the progression of Alzheimer's disease

Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90121-x · Cited by 370 · see citing works

Lesions of the Basal Forebrain Cholinergic System Impair Task Acquisition and Abolish Cortical Plasticity Associated with Motor Skill Learning

Conner, J. M., Culberson, A., Packowski, C., Chiba, A. A., & Tuszynski, M. H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00288-5 · Cited by 352 · see citing works

Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion

Cooper, J. D., Salehi, A., Delcroix, J.-D., Howe, C. L., Belichenko, P. V., Chua-Couzens, J., Kilbridge, J. F., Carlson, E. J., Epstein, C. J., & Mobley, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181219298 · Cited by 336 · see citing works

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

Tuszynski, M. H., U, H., Amaral, D., & Gage, F. H. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03604.1990 · Cited by 281 · see citing works

Surgical and hardware complications of subthalamic stimulation

Lyons, K. E., Wilkinson, S. B., Overman, J. W., & Pahwa, R. (2004) · Neurology · doi:10.1212/01.wnl.0000134650.91974.1a · Cited by 271 · see citing works

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

Smith, D. E., Roberts, J. A., Gage, F. H., & Tuszynski, M. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10893 · Cited by 244 · see citing works

Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice

Capsoni, S., Giannotta, S., & Cattaneo, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192442999 · Cited by 214 · see citing works

Implants of polymer‐encapsulated human NGF‐secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons

Emerich, D. F., Winn, S. R., Harper, J. S., Hammang, J. P., Baetge, E. E., & Kordower, J. H. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903490110 · Cited by 192 · see citing works

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

Korsching, S. I., Heumann, R., Thoenen, H., & Hefti, F. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90186-2 · Cited by 189 · see citing works

Does the cerebellum contribute to specific aspects of attention?

Gottwald, B., Mihajlovic, Z., Wilde, B., & Mehdorn, H. M. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00090-3 · Cited by 169 · see citing works

Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration

Chen, K., & Gage, F. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02819.1995 · Cited by 165 · see citing works

Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration.

Tuszynski, M. H., Roberts, J. A., Senut, M., U, H. S., & Gage, F. H. (1996) · PubMed · Cited by 164 · see citing works

Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease

Potkin, S. G., Anand, R., Fleming, K., Alva, G., Keator, D. B., Carreon, D., Messina, J. C., Wu, J. C., Hartman, R. D., & Fallon, J. H. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002528 · Cited by 158 · see citing works

Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease

Thal, L. J., Grundman, M., Berg, J., Ernstrom, K., Margolin, R., Pfeiffer, E., Weiner, M. F., Zamrini, E., & Thomas, R. G. (2003) · Neurology · doi:10.1212/01.wnl.0000096376.03678.c1 · Cited by 156 · see citing works

Growth-factor gene therapy for neurodegenerative disorders

Tuszynski, M. H. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00006-6 · Cited by 125 · see citing works

Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation

Conner, J. M., Darracq, M. A., Roberts, J., & Tuszynski, M. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1941 · Cited by 116 · see citing works

Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.

Tuszynski, M. H., & Gage, F. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4621 · Cited by 99 · see citing works

Neuronal plasticity of interrelated cerebellar and cortical networks

Molinari, M., Filippini, V., & Leggio, M. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00024-6 · Cited by 95 · see citing works

Alzheimer's disease: Targeting the Cholinergic System

H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551 · see citing works

Alzheimer’s disease: Clinical trials and drug development

Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60982-9 · Cited by 1,067 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works

Network abnormalities and interneuron dysfunction in Alzheimer disease

Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022 · see citing works

Therapeutic interventions after spinal cord injury

Thuret, S., Moon, L. D. F., & Gage, F. H. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1955 · Cited by 1,012 · see citing works

Brain-derived neurotrophic factor in neurodegenerative diseases

Zuccato, C., & Cattaneo, E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.54 · Cited by 947 · see citing works

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820 · see citing works

Stem cells for the treatment of neurological disorders

Lindvall, O., & Kokaia, Z. (2006) · Nature · doi:10.1038/nature04960 · Cited by 829 · see citing works

Advances in the Treatment of Prolactinomas

Gillam, M. P., Molitch, M. E., Lombardi, G., & Colao, A. A. L. (2006) · Endocrine Reviews · doi:10.1210/er.2005-9998 · Cited by 820 · see citing works

From basics to clinical: A comprehensive review on spinal cord injury

Silva, N. A., Sousa, N., Reis, R. L., & Salgado, A. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.002 · Cited by 814 · see citing works

A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease

Laxton, A. W., Tang‐Wai, D. F., McAndrews, M. P., Zumsteg, D., Wennberg, R. A., Keren, R., Wherrett, J. R., Naglie, G., Hamani, C., Smith, G. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22089 · Cited by 808 · see citing works

Therapeutics of Alzheimer's disease: Past, present and future

Anand, R., Gill, K. D., & Mahdi, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.004 · Cited by 748 · see citing works

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 671 · see citing works

Cell death in the nervous system

Bredesen, D. E., Rao, R. V., & Mehlen, P. (2006) · Nature · doi:10.1038/nature05293 · Cited by 638 · see citing works

Neurotrophin signalling in health and disease

Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 626 · see citing works

Stem cells in human neurodegenerative disorders--time for clinical translation?

Lindvall, O., & Kokaia, Z. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40543 · Cited by 623 · see citing works

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

Mufson, E. J., Counts, S., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 589 · see citing works

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579 · see citing works

100 Years and Counting: Prospects for Defeating Alzheimer's Disease

Roberson, E. D., & Mucke, L. (2006) · Science · doi:10.1126/science.1132813 · Cited by 550 · see citing works

Alzheimer Disease

Castellani, R. J., Rolston, R. K., & Smith, M. A. (2010) · Disease-a-Month · doi:10.1016/j.disamonth.2010.06.001 · Cited by 561 · see citing works

HIV and antiretroviral therapy in the brain: neuronal injury and repair

Ellis, R. J., Langford, D., & Masliah, E. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2040 · Cited by 517 · see citing works

Nerve growth factor: from the early discoveries to the potential clinical use

Aloe, L., Rocco, M. L., Bianchi, P., & Manni, L. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-239 · Cited by 460 · see citing works

The use of PET in Alzheimer disease

Nordberg, A. K., Rinne, J. O., Kadir, A., & Långström, B. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.217 · Cited by 451 · see citing works

Stem cell‐based cell therapy in neurological diseases: A review

Kim, S. U., & de Vellis, J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22054 · Cited by 426 · see citing works

The Neurotrophin Family of Neurotrophic Factors: An Overview

Skaper, S. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-536-7_1 · Cited by 380 · see citing works

Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research

Hampel, H. J., Mesulam, M. M., Cuello, A. C., Khachaturian, A. S., Vergallo, A., Farlow, M. R., Snyder, P. J., Giacobini, E., & Khachaturian, Z. S. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2018.43 · Cited by 369 · see citing works

Cellular imaging in drug discovery

Lang, P., Yeow, K., Nichols, A. C., & Scheer, A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2008 · Cited by 349 · see citing works

The stem cell secretome and its role in brain repair

Drago, D., Cossetti, C., Iraci, N., Gaude, E., Musco, G., Bachi, A., & Pluchino, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.06.020 · Cited by 345 · see citing works

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

Schindowski, K., Bélarbi, K., & Buée, L. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00378.x · Cited by 335 · see citing works

Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury

Keefe, K. M., Sheikh, I. S., & Smith, G. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030548 · Cited by 324 · see citing works

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

Salomone, S., Caraci, F., Leggio, G. M., Fedotova, J., & Drago, F. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04134.x · Cited by 322 · see citing works

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

Harris, J. A., Devidze, N., Verret, L., Ho, K., Halabisky, B., Thwin, M. T., Kim, D., Hamto, P., Lo, I., Yu, G.-Q., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.020 · Cited by 319 · see citing works

Clinical relevance of the neurotrophins and their receptors

Allen, S. J., & Dawbarn, D. (2006) · Clinical Science · doi:10.1042/cs20050161 · Cited by 316 · see citing works

Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease

Tuszynski, M. H., Yang, J. H., Barba, D., U, H.-S., Bakay, R. A. E., Pay, M. M., Masliah, E., Conner, J. M., Kobalka, P., Roy, S., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1807 · Cited by 287 · see citing works

Advances in developing novel therapeutic strategies for Alzheimer’s disease

Cao, J., Hou, J., Ping, J., & Cai, D. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0299-8 · Cited by 283 · see citing works

Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease

Grothe, M. J., Heinsen, H., & Teipel, S. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.019 · Cited by 283 · see citing works

Disease-modifying therapies for Alzheimer disease

Cummings, J. L., Doody, R. S., & Clark, C. (2007) · Neurology · doi:10.1212/01.wnl.0000295996.54210.69 · Cited by 281 · see citing works

Serum neurotrophins—A study on the time course and influencing factors in a large old age sample

Ziegenhorn, A. A., Schulte‐Herbrüggen, O., Danker‐Hopfe, H., Malbranc, M., Hartung, H.-D., Anders, D., Lang, U. E., Steinhagen‐Thiessen, E., Schaub, R., & Hellweg, R. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.011 · Cited by 277 · see citing works

Gene therapy: can neural stem cells deliver?

Müller, F.-J., Snyder, E. Y., & Loring, J. F. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1829 · Cited by 275 · see citing works

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Pohl, F., & Lin, P. K. T. (2018) · Molecules · doi:10.3390/molecules23123283 · Cited by 281 · see citing works

Viral vectors for gene delivery to the central nervous system

Lentz, T. B., Gray, S. J., & Samulski, R. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.014 · Cited by 274 · see citing works

Stem cell technology for neurodegenerative diseases

Lunn, J. S., Sakowski, S. A., Hur, J., & Feldman, E. L. (2011) · Annals of Neurology · doi:10.1002/ana.22487 · Cited by 272 · see citing works

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Minati, L., Edginton, T. L., Bruzzone, M. G., & Giaccone, G. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317508328602 · Cited by 266 · see citing works

Aβ-degrading enzymes: potential for treatment of Alzheimer disease

Miners, J. S., Barua, N., Kehoe, P. G., Gill, S., & Love, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182345e46 · Cited by 265 · see citing works

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

Kuhn, J., Hardenacke, K., Lenartz, D., Gruendler, T. O. J., Ullsperger, M., Bartsch, C., Mai, J. K., Zilles, K., Bauer, A., Matusch, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.32 · Cited by 262 · see citing works

Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

Ginsberg, S. D., Che, S., Wuu, J., Counts, S., & Mufson, E. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03764.x · Cited by 255 · see citing works

Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma

Lambìase, A., Aloe, L., Centofanti, M., Parisi, V., Mantelli, F., Colafrancesco, V., Manni, G., Bucci, M. G., Bonini, S., & Levi‐Montalcini, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906678106 · Cited by 245 · see citing works

Neurotrophic Factors: An Overview

Skaper, S. D. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7571-6_1 · Cited by 242 · see citing works

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

Blesch, A., & Tuszynski, M. H. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.008 · Cited by 238 · see citing works

Pathogenesis of Alzheimer's disease.

Swerdlow, R. H. (2007) · PubMed Central · Cited by 236 · see citing works

Nerve Growth Factor: A Focus on Neuroscience and Therapy

Aloe, L., Rocco, M., Balzamino, B. O., & Micera, A. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150403231920 · Cited by 240 · see citing works

The Role of Nerve Growth Factor Receptors in Cholinergic Basal Forebrain Degeneration in Prodromal Alzheimer Disease

Counts, S., & Mufson, E. J. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.4.263 · Cited by 222 · see citing works

A review on advances of treatment modalities for Alzheimer's disease

Thoe, E. S., Fauzi, A., Tang, Y.-Q., Chamyuang, S., & Chia, A. Y. Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119129 · Cited by 224 · see citing works

Adeno-Associated Viral Vector (Serotype 2)–Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial

Rafii, M. S., Tuszynski, M. H., Thomas, R. G., Barba, D., Brewer, J. B., Rissman, R. A., Siffert, J., Aisen, P. S., & for the AAV2-NGF Study Team (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0233 · Cited by 219 · see citing works

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

Pinton, S., Sampaio, T. B., Savall, A. S. P., & Gutierrez, M. Z. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.205084 · Cited by 219 · see citing works

Cellular Transplants in China: Observational Study from the Largest Human Experiment in Chronic Spinal Cord Injury

Dobkin, B. H., Curt, A. E. P., & Guest, J. D. (2006) · Neurorehabilitation and neural repair · doi:10.1177/1545968305284675 · Cited by 216 · see citing works

Contributions of non-human primates to neuroscience research

Capitanio, J. P., & Emborg, M. E. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60489-4 · Cited by 214 · see citing works

Current advances in using neurotrophic factors to treat neurodegenerative disorders

Weissmiller, A. M., & Wu, C. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-14 · Cited by 211 · see citing works

Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration

Kimura, A. K., Namekata, K., Guo, X., Harada, C., & Harada, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091584 · Cited by 214 · see citing works

The limited application of stem cells in medicine: a review

Poulos, J. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0735-7 · Cited by 211 · see citing works

Neurotrophins, synaptic plasticity and dementia

Arancio, O., & Chao, M. V. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.013 · Cited by 193 · see citing works

Comparison of 18F-FDG and PiB PET in Cognitive Impairment

Lowe, V. J., Kemp, B. J., Jack, C. R., Senjem, M. L., Weigand, S. D., Shiung, M. S., Smith, G. E., Knopman, D. S., Boeve, B. F., Mullan, B. P., et al. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058529 · Cited by 193 · see citing works

Factors that influence adult neurogenesis as potential therapy

Shohayeb, B., Diab, M., Ahmed, M., & Ng, D. C. H. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0109-9 · Cited by 195 · see citing works

Adeno-Associated Virus (AAV) Vectors in the CNS

McCown, T. J. (2005) · Current Gene Therapy · doi:10.2174/1566523054064995 · Cited by 187 · see citing works

Gene-based therapies for neurodegenerative diseases

Sun, J., & Roy, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00778-1 · Cited by 189 · see citing works

Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications

Wong, L., Goodhead, L., Prat, C. M. A., Mitrophanous, K. A., Kingsman, S. M., & Mazarakis, N. D. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.1 · Cited by 184 · see citing works

Synthesis of (+)-Complanadine A, an Inducer of Neurotrophic Factor Excretion

Yuan, C., Chang, C.-T., Axelrod, A. J., & Siegel, D. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja101956x · Cited by 180 · see citing works

Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease

Grothe, M. J., Heinsen, H., & Teipel, S. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.018 · Cited by 179 · see citing works

The Neurotrophins and Their Role in Alzheimers Disease

Allen, S. J., Watson, J. J., & Dawbarn, D. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376190 · Cited by 177 · see citing works

Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice

Nagahara, A. H., Mateling, M., Kovács, I., Wang, L., Eggert, S., Rockenstein, E. M., Koo, E. H., Masliah, E., & Tuszynski, M. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5195-12.2013 · Cited by 176 · see citing works

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

Chen, X., & Mobley, W. C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00446 · Cited by 174 · see citing works

Current approaches in the treatment of Alzheimer's disease

Shah, R. S., Lee, H., Zhu, X., Perry, G. L., Smith, M. A., & Castellani, R. J. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.005 · Cited by 176 · see citing works

NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons

Matrone, C., Ciotti, M. T., Mercanti, D., Marolda, R., & Calissano, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806133105 · Cited by 169 · see citing works

Neural stem cell‐based treatment for neurodegenerative diseases

Kim, S. U., Lee, H. J., & Kim, Y. B. (2013) · Neuropathology · doi:10.1111/neup.12020 · Cited by 169 · see citing works

Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

Behrstock, S. P., Ebert, A. D., McHugh, J., Vosberg, S. K., Moore, J. M., Schneider, B. L., Capowski, E. E., Hei, D. J., Kordower, J. H., Aebischer, P., et al. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302679 · Cited by 168 · see citing works

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

Lee, I.-S., Jung, K., Kim, I., Lee, H.-J., Kim, M., Yun, S., Hwang, K., Shin, J. E., & Park, K. I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0035-6 · Cited by 168 · see citing works

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model

Evers, M. M., Miniarikova, J., Juhas, S., Vallès, A., Bohuslavova, B., Juhasova, J., Skalnikova, H. K., Vodicka, P., Valekova, I., Brouwers, C., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.021 · Cited by 168 · see citing works

HIV and antiretroviral therapy in the brain: neuronal injury and repair

Ellis, R. J., Langford, D., Masliah, E., Grant, I., Heaton, R. K., Wong, J. K., Smith, D. M., Letendre, S. L., & McCutchan, A. (2008) · BMC Proceedings · doi:10.1186/1753-6561-2-s1-s13 · Cited by 167 · see citing works

Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

Wang, J., Li, Z., Pan, M., Fiaz, M., Hao, Y., Yan, Y., Sun, L., & Yan, F. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114539 · Cited by 161 · see citing works

Disease‐modifying therapies in Alzheimer's disease

Salloway, S., Mintzer, J. E., Weiner, M., & Cummings, J. L. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.10.001 · Cited by 161 · see citing works

Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

Xu, D., Wu, D., Qin, M., Nih, L. R., Liu, C., Cao, Z., Ren, J., Chen, X., He, Z., Yu, W., et al. (2019) · Advanced Materials · doi:10.1002/adma.201900727 · Cited by 161 · see citing works

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

Mitra, S., Behbahani, H., & Eriksdotter, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00038 · Cited by 159 · see citing works

Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention.

Kidd, P. M. (2008) · PubMed · Cited by 158 · see citing works

Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer’s Disease

Eriksdotter, M., Linderoth, B., Lind, G., Aladellie, L., Almkvist, O., Andreasen, N., Blennow, K., Bogdanović, N., Jelić, V., Kadir, A., et al. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000336051 · Cited by 158 · see citing works

The synapse as a treatment avenue for Alzheimer’s Disease

Peng, L., Bestard‐Lorigados, I., & Song, W. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01565-z · Cited by 158 · see citing works

Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions

Lowenstein, P. R., Mandel, R. J., Xiong, W.-D., Kroeger, K. M., & Castro, M. G. (2007) · Current Gene Therapy · doi:10.2174/156652307782151498 · Cited by 157 · see citing works

Nerve growth factor promotes survival of new neurons in the adult hippocampus

Frielingsdorf, H., Simpson, D. R., Thal, L. J., & Pizzo, D. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.015 · Cited by 151 · see citing works

Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease

Danielyan, L., Beer‐Hammer, S., Stolzing, A., Schäfer, R., Siegel, G., Fabian, C., Kahle, P. J., Biedermann, T., Lourhmati, A., Buadze, M., et al. (2014) · Cell Transplantation · doi:10.3727/096368914x684970 · Cited by 150 · see citing works

Microenvironmental regulation of biomacromolecular therapies

Kong, H. J., & Mooney, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2309 · Cited by 147 · see citing works

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

Kiyota, T., Dixie, K. L. I., Jacobsen, M. T., Xiong, H., & Ikezu, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102349108 · Cited by 146 · see citing works

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound

Burgess, A., & Hynynen, K. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300191b · Cited by 142 · see citing works

NAP: Research and Development of a Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP)

Gozes, I., Morimoto, B. H., Tiong, J., Fox, A. W., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P. E., Aisen, P. S. S., et al. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00053.x · Cited by 144 · see citing works

Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy

Corti, S. P., Nizzardo, M., Nardini, M., Donadoni, C., Salani, S., Ronchi, D., Saladino, F., Bordoni, A., Fortunato, F., Bo, R. D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35432 · Cited by 142 · see citing works

Anti‐nerve growth factor monoclonal antibodies for the control of pain in dogs and cats

Enomoto, M., Mantyh, P. W., Murrell, J. C., Innes, J., & Lascelles, B. D. X. (2018) · Veterinary Record · doi:10.1136/vr.104590 · Cited by 142 · see citing works

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

Garcia, P., Youssef, I., Utvik, J. K., Florent-Béchard, S., Barthélémy, V., Malaplate-Armand, C., Kriem, B., Stenger, C., Koziel, V., Olivier, J.-L., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4182-09.2010 · Cited by 139 · see citing works

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

Wu, D., Qin, M., Xu, D., Wang, L., Liu, C., Ren, J., Zhou, G. W., Chen, C., Yang, F., Li, Y., et al. (2019) · Advanced Materials · doi:10.1002/adma.201807557 · Cited by 138 · see citing works

Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)01223-7 · Cited by 137 · see citing works

S3–04–02: NGF gene therapy

Tuszynski, M. H., Thal, L. J., Pay, M. M., Tong, G., Hoi-Sang, U., Bakay, R. A. E., Potkin, S. G., Ho, G. J., Bartus, R. T., Arvanitakis, Z., et al. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.181 · Cited by 1 · see citing works

Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease

Tuszynski, M. H., Yang, J. H., Barba, D., U, H.-S., Bakay, R. A. E., Pay, M. M., Masliah, E., Conner, J. M., Kobalka, P., Roy, S., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1807 · Cited by 287 · see citing works

Research Highlights

(2005) · Nature Biotechnology · doi:10.1038/nbt0505-559 · Cited by 1 · see citing works

Hope for AD with NGF gene-therapy trial

Bradbury, J. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70086-7 · Cited by 30 · see citing works

Intracranial infusion of purified nerve growth factor to an Alzheimer patient: The first attempt of a possible future treatment strategy

Seiger, Å., Nordberg, A. K., von Holst, H., Bäckman, L., Ebendal, T., Alafuzoff, I. I., Amberla, K., Hartvig, P., Herlitz, A., Lilja, A., et al. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90141-c · Cited by 137 · see citing works