The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
BK Ca -Cav Channel Complexes Mediate Rapid and Localized Ca 2+ -Activated K + Signaling
Abstract
Large-conductance calcium- and voltage-activated potassium channels (BK Ca ) are dually activated by membrane depolarization and elevation of cytosolic calcium ions (Ca 2+ ). Under normal cellular conditions, BK Ca channel activation requires Ca 2+ concentrations that typically occur in close proximity to Ca 2+ sources. We show that BK Ca channels affinity-purified from rat brain are assembled into macromolecular complexes with the voltage-gated calcium channels Cav1.2 (L-type), Cav2.1 (P/Q-type), and Cav2.2 (N-type). Heterologously expressed BK Ca -Cav complexes reconstitute a functional “Ca 2+ nanodomain” where Ca 2+ influx through the Cav channel activates BK Ca in the physiological voltage range with submillisecond kinetics. Complex formation with distinct Cav channels enables BK Ca -mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system.
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Citations
Cites
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Calcium-activated potassium channels
Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80056-1 · Cited by 954
Cited by
The action potential in mammalian central neurons
Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
Schwenk, J., Harmel, N., Brechet, A., Zolles, G., Berkefeld, H., Müller, C. S., Bildl, W., Baehrens, D., Hüber, B., Kulik, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.034 · Cited by 433
Self-citationBraun, M., Ramracheya, R., Bengtsson, M., Zhang, Q., Karanauskaite, J., Partridge, C., Johnson, P. R., & Rorsman, P. (2008) · Diabetes · doi:10.2337/db07-0991 · Cited by 417
Bucurenciu, I., Kulik, A., Schwaller, B., Frotscher, M., & Jonas, P. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.026 · Cited by 274
Ca2+-Activated K+Channels: From Protein Complexes to Function
Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274
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Metadata
- Authors
- Berkefeld, H., Sailer, C. A., Bildl, W., Rohde, V., Thumfart, J.-O., Eble, S., Klugbauer, N., Reisinger, E., Bischofberger, J., Oliver, D., Knaus, H.-G., Schulte, U., & Fakler, B.
- Venue
- Science
- Published
- 2006-10-27
- Volume
- 314
- Issue
- 5799
- Pages
- 615-620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072081603
- Cited by
- 373
- References
- 2
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
