Cited by 274Neuroscience and Neuropharmacology ResearchIon channel regulation and functionCellular transport and secretion

Nanodomain Coupling between Ca2+ Channels and Ca2+ Sensors Promotes Fast and Efficient Transmitter Release at a Cortical GABAergic Synapse

Open access
Bucurenciu, Iancu, Kulik, Akos, Schwaller, Beat, Frotscher, Michael, Jonas, Peter·2008·Neuron

Abstract

It is generally thought that transmitter release at mammalian central synapses is triggered by Ca2+ microdomains, implying loose coupling between presynaptic Ca2+ channels and Ca2+ sensors of exocytosis. Here we show that Ca2+ channel subunit immunoreactivity is highly concentrated in the active zone of GABAergic presynaptic terminals of putative parvalbumin-containing basket cells in the hippocampus. Paired recording combined with presynaptic patch pipette perfusion revealed that GABA release at basket cell-granule cell synapses is sensitive to millimolar concentrations of the fast Ca2+ chelator BAPTA but insensitive to the slow Ca2+ chelator EGTA. These results show that Ca2+ source and Ca2+ sensor are tightly coupled at this synapse, with distances in the range of 10-20 nm. Models of Ca2+ inflow-exocytosis coupling further reveal that the tightness of coupling increases efficacy, speed, and temporal precision of transmitter release. Thus, tight coupling contributes to fast feedforward and feedback inhibition in the hippocampal network.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2007.12.026

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Modeling of Ca2+ domains showed that tightening of coupling increases Pr approximately 10-fold per 20 nm change in coupling distance.

    “Modeling of Ca2+ domains showed that tightening of coupling increases Pr approximately 10-fold per 20 nm change in coupling distance [87,88].”
  • The short physical distance between the site of Ca2+ entry and the synaptic release machinery enforces a tight coupling between action potential invasion and neurotransmitter release with rapid and precise temporal dynamics.

    “The short physical distance between the site of Ca2+ entry and the synaptic release machinery enforces a tight coupling between action potential invasion and neurotransmitter release with rapid and precise temporal dynamics (132, 477).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [132]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bucurenciu, I., Kulik, A., Schwaller, B., Frotscher, M., & Jonas, P.
Affiliations
  • University of Freiburg (DE)
  • University of Fribourg (CH)
Venue
Neuron
Publisher
Elsevier BV
Published
2008-02
Volume
57
Issue
4
Pages
536-545
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2033866317
Cited by
274
References
51
Citations by year
2026: 8 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 11 · 2020: 7 · 2019: 14 · 2018: 21 · 2017: 16 · 2016: 10 · 2015: 19 · 2014: 24 · 2013: 12 · 2012: 20
FWCI
9.23
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
calcium microdomains, GABAergic synapses, basket cells, parvalbumin, active zone, exocytosis, neurotransmitter release, BAPTA, EGTA, calcium chelation, hippocampus, granule cells, feedforward inhibition, product inhibition
MeSH terms
Animals, gamma-Aminobutyric Acid, Hippocampus, Synaptic Transmission, Synapses, Calcium Channels, Rats, Wistar, Calcium Signaling, Nanotechnology, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review