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Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis
Open accessAbstract
The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the responsible genes, we mapped virulence in F 1 progeny derived from crosses between type II and type III strains, which we introduced into mice. Five virulence ( VIR ) loci were thus identified, and for two of these, genetic complementation showed that a predicted protein kinase (ROP18 and ROP16, respectively) is the key molecule. Both are hypervariable rhoptry proteins that are secreted into the host cell upon invasion. These results suggest that secreted kinases unique to the Apicomplexa are crucial in the host-pathogen interaction.
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Citations
Cited by
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes
Sidik, S. M., Huet, D., Ganesan, S. M., Huynh, M.-H., Wang, T., Nasamu, A. S., Thiru, P., Saeij, J. P. J., Carruthers, V. B., Niles, J. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.019 · Cited by 804
Self-citationKiss and spit: the dual roles of Toxoplasma rhoptries
Boothroyd, J. C., & Dubremetz, J.-F. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1800 · Cited by 406
Self-citationToxoplasma Effectors Targeting Host Signaling and Transcription
Hakimi, M.-A., Olias, P., & Sibley, L. D. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00005-17 · Cited by 339
Self-citationInvasion and intracellular survival by protozoan parasites
David Sibley, L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00990.x · Cited by 254
Innate responses to Toxoplasma gondii in mice and humans
Pifer, R., & Yarovinsky, F. (2011) · Trends in Parasitology · doi:10.1016/j.pt.2011.03.009 · Cited by 139
Metadata
- Authors
- Saeij, J. P. J., Boyle, J. P., Coller, S., Taylor, S., Sibley, L. D., Brooke-Powell, E. T., Ajioka, J. W., & Boothroyd, J. C.
- Venue
- Science
- Published
- 2006-12-15
- Volume
- 314
- Issue
- 5806
- Pages
- 1780-1783
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993484262
- Cited by
- 602
- References
- 0
- FWCI
- 18.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Saeij, J. P. J., Boyle, J. P., Coller, S., Taylor, S., Sibley, L. D., Brooke-Powell, E. T., Ajioka, J. W., & Boothroyd, J. C. (2006). Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis. Science. https://doi.org/10.1126/science.1133690
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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