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Evolutionary History of Salmonella Typhi
Open accessAbstract
For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.
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Citations
Cited by
BIGSdb: Scalable analysis of bacterial genome variation at the population level
Jolley, K. A., & Maiden, M. C. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-595 · Cited by 2,368
Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-15 · Cited by 1,156
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
Feasey, N. A., Dougan, G., Kingsley, R. A., Heyderman, R. S., & Gordon, M. A. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61752-2 · Cited by 1,014
Self-citationThe Population Genetics of dN/dS
Kryazhimskiy, S., & Plotkin, J. B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000304 · Cited by 962
“This point is illustrated by two recent studies that report dN/dS ratios near 1 among strains of Salmonella enetrica serovar Typhi [17,18], and conclude that genetic drift dominates the bacterium’s evolution.”
BackgroundResultInfluentialMultilocus sequence typing as a replacement for serotyping in Salmonella enterica
Achtman, M., Wain, J., Weill, F.-X., Nair, S., Zhou, Z., Sangal, V., Krauland, M. G., Hale, J. L., Harbottle, H., Uesbeck, A., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002776 · Cited by 710
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Metadata
- Authors
- Roumagnac, P., Weill, F.-X., Dolecek, C., Baker, S., Brisse, S., Chinh, N. T., Le, T. A. H., Acosta, C. J., Farrar, J., Dougan, G., & Achtman, M.
- Venue
- Science
- Published
- 2006-11-24
- Volume
- 314
- Issue
- 5803
- Pages
- 1301-1304
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051727227
- Cited by
- 364
- References
- 0
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Roumagnac, P., Weill, F.-X., Dolecek, C., Baker, S., Brisse, S., Chinh, N. T., Le, T. A. H., Acosta, C. J., Farrar, J., Dougan, G., & Achtman, M. (2006). Evolutionary History of Salmonella Typhi. Science. https://doi.org/10.1126/science.1134933
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