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A Cytochrome c Oxidase Model Catalyzes Oxygen to Water Reduction Under Rate-Limiting Electron Flux
Open accessAbstract
We studied the selectivity of a functional model of cytochrome c oxidase's active site that mimics the coordination environment and relative locations of Fe a3 , Cu B , and Tyr 244 . To control electron flux, we covalently attached this model and analogs lacking copper and phenol onto self-assembled monolayer–coated gold electrodes. When the electron transfer rate was made rate limiting, both copper and phenol were required to enhance selective reduction of oxygen to water. This finding supports the hypothesis that, during steady-state turnover, the primary role of these redox centers is to rapidly provide all the electrons needed to reduce oxygen by four electrons, thus preventing the release of toxic partially reduced oxygen species.
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Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
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Yang, S., Feng, X., Wang, X., & Müllen, K. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100170 · Cited by 1,109
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Lu, B., Liu, Q., & Chen, S. (2020) · ACS Catalysis · doi:10.1021/acscatal.0c01950 · Cited by 394
Cytochrome c oxidase dysfunction in oxidative stress
Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 373
Chemical modifications of proteins and their applications in metalloenzyme studies
Naowarojna, N., Cheng, R., Lopez, J., Wong, C., Qiao, L., & Liu, P. (2021) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.01.001 · Cited by 52
Metadata
- Authors
- Collman, J. P., Devaraj, N. K., Decréau, R. A., Yang, Y., Yan, Y.-L., Ebina, W., Eberspacher, T. A., & Chidsey, C. E. D.
- Venue
- Science
- Published
- 2007-03-16
- Volume
- 315
- Issue
- 5818
- Pages
- 1565-1568
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080662803
- Cited by
- 554
- References
- 1
- FWCI
- 21.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Collman, J. P., Devaraj, N. K., Decréau, R. A., Yang, Y., Yan, Y.-L., Ebina, W., Eberspacher, T. A., & Chidsey, C. E. D. (2007). A Cytochrome c Oxidase Model Catalyzes Oxygen to Water Reduction Under Rate-Limiting Electron Flux. Science. https://doi.org/10.1126/science.1135844
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
