The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Open accessAbstract
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8 + DCs that express the cell surface protein CD205, CD8 – DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
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Self-citationMouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature Reviews Immunology · doi:10.1038/nri746 · Cited by 2,291
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
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Self-citationGermain, R. N. (1994) · Cell · doi:10.1016/0092-8674(94)90336-0 · Cited by 1,434
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
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Self-citationCELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO
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Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate
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The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo
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Self-citation
Cited by
Fcγ receptors as regulators of immune responses
Nimmerjahn, F., & Ravetch, J. V. (2008) · Nature Reviews Immunology · doi:10.1038/nri2206 · Cited by 2,947
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2868 · Cited by 2,106
Metadata
- Authors
- Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., Steinman, R. M., & Nussenzweig, M. C.
- Venue
- Science
- Published
- 2007-01-05
- Volume
- 315
- Issue
- 5808
- Pages
- 107-111
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2137670912
- Cited by
- 1,455
- References
- 27
- FWCI
- 38.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., Steinman, R. M., & Nussenzweig, M. C. (2007). Differential Antigen Processing by Dendritic Cell Subsets in Vivo. Science. https://doi.org/10.1126/science.1136080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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