The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

Merad, Miriam; Sathe, Priyanka; Helft, Julie; Miller, Jennifer; Mortha, Arthur

doi:10.1146/annurev-immunol-020711-074950

Cited by 2,309Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

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Merad, Miriam, Sathe, Priyanka, Helft, Julie, Miller, Jennifer, Mortha, Arthur·2013·Annual Review of Immunology

DOI 10.1146/annurev-immunol-020711-074950PMC PMC3853342

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Abstract

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

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STAT3 plays major roles in immature dendritic cell development and function, affecting both plasmacytoid DCs and conventional DCs.
“STAT3 also plays major roles in immature DC development and function”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Merad et al., 2013
The STATs section reports that STAT3 has a nonredundant role in DC development and that mice lacking it have profound reductions in DCs and pDCs. It does not establish a role for STAT3 in immature DC function or specifically identify immature DCs as the affected population; no page number is available in our copy. (LLM, conf=0.87)
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[56]Bar-On L Birnberg T Lewis KL Edelson BT Bruder D 2010 CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells Proc Natl Acad Sci USA 107 14745 50 20679228 PMC2930429
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[239]Satpathy AT Wumesh KC Albring JC Edelson BT Kretzer NM 2012 Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages J Exp Med 209 1135 52 22615127 PMC3371733
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Authors: Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A.
Affiliations: Department of Oncological Sciences,
ORCID: Helft, Julie
Mortha, Arthur
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2013-03-21
Volume: 31
Issue: 1
Pages: 563-604
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-020711-074950
PMC: PMC3853342
OpenAlex: W2168028214
Cited by: 2,309
References: 302
Citations by year: 2026: 78 · 2025: 106 · 2024: 150 · 2023: 157 · 2022: 187 · 2021: 209 · 2020: 232 · 2019: 225 · 2018: 209 · 2017: 192 · 2016: 187 · 2015: 172 · 2014: 150 · 2013: 54
FWCI: 16.37
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA173861)
National Institute of Allergy and Infectious Diseases (U01AI095611)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: dendritic cells, dendritic cell lineage, hematopoietic lineage, dendritic cell differentiation, dendritic cell subsets, steady-state immunity, inflammation, adaptive immune response
MeSH terms: Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Humans, Inflammation, Lymphoid Tissue, Inflammation Mediators, Cell Lineage

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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

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