The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity
Abstract
IKKϵ is an IKK (inhibitor of nuclear factor κBkinase)–related kinase implicated in virus induction of interferon-β (IFNβ). We report that, although mice lacking IKKϵ produce normal amounts of IFNβ, they are hypersusceptible to viral infection because of a defect in the IFN signaling pathway. Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of IKKϵ because the interferon-stimulated gene factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes. We demonstrate that IKKϵ is activated by IFNβ and that IKKϵ directly phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of ISGF3. We conclude that IKKϵ plays a critical role in the IFN-inducible antiviral transcriptional response.
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Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730
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Metadata
- Authors
- tenOever, B. R., Ng, S.-L., Chua, M. A., McWhirter, S. M., García-Sastre, A., & Maniatis, T.
- Venue
- Science
- Published
- 2007-03-02
- Volume
- 315
- Issue
- 5816
- Pages
- 1274-1278
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091906420
- Cited by
- 342
- References
- 1
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- tenOever, B. R., Ng, S.-L., Chua, M. A., McWhirter, S. M., García-Sastre, A., & Maniatis, T. (2007). Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity. Science. https://doi.org/10.1126/science.1136567
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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