Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

Hill, C. S., & Treisman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90403-4 · Cited by 1,263 · see citing works

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210 · see citing works

Transcriptional activation by recruitment

Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158 · see citing works

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014 · see citing works

CREB-binding protein/p300 are transcriptional coactivators of p65

Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 811 · see citing works

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649 · see citing works

Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking

Orlando, V., Strutt, H. L., & Paro, R. (1997) · Methods · doi:10.1006/meth.1996.0407 · Cited by 607 · see citing works

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533 · see citing works

The p300/CBP family: integrating signals with transcription factors and chromatin

Shiama, N. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01048-9 · Cited by 481 · see citing works

Activators and targets

Ptashne, M., & Gann, A. A. F. (1990) · Nature · doi:10.1038/346329a0 · Cited by 455 · see citing works

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

Merika, M., Williams, A. J., Chen, G., Collins, T., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80028-3 · Cited by 435 · see citing works

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

Escalante, C. R., Yie, J., Thanos, D., & Aggarwal, A. K. (1998) · Nature · doi:10.1038/34224 · Cited by 397 · see citing works

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

Au, W.-C., Moore, P. A., Lowther, W. J., Juang, Y., & Pitha, P. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11657 · Cited by 388 · see citing works

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

Fujita, T., Kimura, Y., Miyamoto, M., Barsoumian, E. L., & Taniguchi, T. (1989) · Nature · doi:10.1038/337270a0 · Cited by 358 · see citing works

The Mechanism of Transcriptional Synergy of an In Vitro Assembled Interferon-β Enhanceosome

Kim, T. K., & Maniatis, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80013-1 · Cited by 340 · see citing works

Untitled work

(1995) · PubMed · Cited by 312 · see citing works

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Fujita, T., Reis, L. F. L., Watanabe, N., Kimura, Y., Taniguchi, T., & Vilček, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9936 · Cited by 287 · see citing works

IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency

Zhang, L.-W., & Pagano, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5748 · Cited by 277 · see citing works

Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes.

Reis, L. F. L., Harada, H., Wolchok, J. D., Taniguchi, T., & Vilček, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05041.x · Cited by 243 · see citing works

Transcriptional control: Versatile molecular glue

Janknecht, R., & Hunter, T. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00636-x · Cited by 230 · see citing works

Triple post‐transcriptional control

Bechhofer, D. H. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb02051.x · Cited by 204 · see citing works

IκB kinase: Beginning, not the end

Verma, I. M., & Stevenson, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11758 · Cited by 199 · see citing works

Mice devoid of interferon regulatory factor 1 (IRF‐1) show normal expression of type I interferon genes.

Reis, L. F. L., Ruffner, H., Stark, G., Aguet, M., & Weissmann, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06805.x · Cited by 184 · see citing works

Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3

Bandyopadhyay, S. K., Leonard, G. T., Bandyopadhyay, T., Stark, G. R., & Sen, G. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19624 · Cited by 140 · see citing works

New inducers revealed by the promoter sequence analysis of two interferon-activated human genes

WATHELET, M. G., CLAUSS, I. M., Nols, C. B., Content, J., & Huez, G. A. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13614.x · Cited by 105 · see citing works

Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons.

Miyakoshi, J., Dobler, K., Allalunis‐Turner, J., McKean, J. D. S., Petruk, K. C., Allen, P. B., Aronyk, K. N., Weir, B., Huyser-Wierenga, D., & Fulton, D. S. (1990) · PubMed · Cited by 104 · see citing works

The Myb oncoprotein: regulating a regulator

Ness, S. A. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00027-3 · Cited by 101 · see citing works

Regulation of gene expression by cytokines and virus in human cells lacking the type‐I interferon locus

Wathelet, M. G., BERR, P. M., & Huez, G. A. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16999.x · Cited by 97 · see citing works

p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cellsPreprint

Kawasaki, H., Song, J., Eckner, R., Ugai, H., Chiu, R., Taira, K., Shi, Y., Jones, N., & Yokoyama, K. K. (1998) · Genes & Development · doi:10.1101/gad.12.2.233 · Cited by 90 · see citing works

Characterization of Specific DNA-binding Factors Activated by Double-stranded RNA as Positive Regulators of Interferon α/β-stimulated Genes

Daly, C., & Reich, N. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23739 · Cited by 81 · see citing works

Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo.

Tanaka, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4311 · Cited by 79 · see citing works

Regulation of two interferon‐inducible human genes by interferon, poly(rI) · poly(rC) and viruses

WATHELET, M. G., CLAUSS, I. M., Content, J., & Huez, G. A. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14101.x · Cited by 73 · see citing works

clRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA

Grant, C. E., Vasa, M. Z., & Deeley, R. G. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2137 · Cited by 56 · see citing works

Transcriptional stimulation by CaPO4-DNA precipitates

Pine, R. I., Levy, D. E., Reich, N. C., & Darnell, J. E., Jr. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.4.1371 · Cited by 45 · see citing works

A novel PRD I and TG binding activity involved in virus-induced transcription of IFN-A genes

Génin, P., Bragança, J., Darracq, N., Doly, J., & Civas, A. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5055 · Cited by 35 · see citing works

Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element

Bovolenta, C., Lou, J., Kanno, Y., Park, B. K., Thornton, A. M., Coligan, J. E., Schubert, M., & Ozato, K. (1995) · Journal of Virology · doi:10.1128/jvi.69.7.4173-4181.1995 · Cited by 29 · see citing works

44 Positive and Negative Control of Human Interferon-β Gene ExpressionPreprint

Maniatis, T., Whittemore, L.-A., Du, W., Fan, C., Keller, A., Palombella, V. J., & Thanos, D. (1992) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969425.22b.1193 · Cited by 8 · see citing works

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 3,935 · see citing works

Antiviral Actions of Interferons

Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743 · see citing works

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

Chen, X., Han, X., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.043 · Cited by 2,474 · see citing works

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,676 · see citing works

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,664 · see citing works

IRF Family of Transcription Factors as Regulators of Host Defense

Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658 · see citing works

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

Randall, R. E., & Goodbourn, S. (2007) · Journal of General Virology · doi:10.1099/vir.0.83391-0 · Cited by 1,559 · see citing works

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,513 · see citing works

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00053-4 · Cited by 1,342 · see citing works

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254 · see citing works

The IRF Family Transcription Factors in Immunity and Oncogenesis

Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B. G., Pitha, P. M., & Golenbock, D. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031023 · Cited by 1,193 · see citing works

Multiple control of interleukin-8 gene expression

Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058 · see citing works

Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7

Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science · doi:10.1126/science.aaa3650 · Cited by 966 · see citing works

Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures

Goodbourn, S., Didcock, L., & Randall, R. E. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-10-2341 · Cited by 977 · see citing works

Viruses and Interferons

Sen, G. C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.255 · Cited by 969 · see citing works

Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente

García‐Sastre, A., & Biron, C. A. (2006) · Science · doi:10.1126/science.1125676 · Cited by 880 · see citing works

CREB-binding Protein and p300 in Transcriptional Regulation

Vo, N., & Goodman, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000025200 · Cited by 868 · see citing works

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

Doyle, S. E., Vaidya, S. A., O’Connell, R. M., Dadgostar, H., Dempsey, P. W., Wu, T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00390-4 · Cited by 845 · see citing works

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.

Stojdl, D., Lichty, B., TENOEVER, B., Paterson, J., Power, A., Knowles, S., Marius, R., Reynard, J., Poliquin, L., Atkins, H., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00241-1 · Cited by 894 · see citing works

Activation of innate immune antiviral responses by Nod2

Sabbah, A., Chang, T. H., Harnack, R., Frohlich, V. C., Tominaga, K., Dube, P. H., Xiang, Y., & Bose, S. (2009) · Nature Immunology · doi:10.1038/ni.1782 · Cited by 754 · see citing works

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H. I., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., et al. (2002) · Nature · doi:10.1038/416744a · Cited by 719 · see citing works

The interferon response circuit: Induction and suppression by pathogenic viruses

Haller, O., Kochs, G., & Weber, F. (2005) · Virology · doi:10.1016/j.virol.2005.09.024 · Cited by 679 · see citing works

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666 · see citing works

Inhibition of interferon signaling by dengue virus

Muñoz‐Jordán, J. L., Sánchez-Burgos, G., Laurent-Rolle, M., & García‐Sastre, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335168100 · Cited by 666 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityPreprint

Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M. (1998) · Genes & Development · doi:10.1101/gad.12.13.2061 · Cited by 631 · see citing works

IRF7: activation, regulation, modification and function

Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 590 · see citing works

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598 · see citing works

RNA recognition and signal transduction by RIG‐I‐like receptors

Yoneyama, M., & Fujita, T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00727.x · Cited by 594 · see citing works

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

Pérez-Caballero, D., Zang, T. M., Ebrahimi, A., McNatt, M. W., Gregory, D. A., Johnson, M. C., & Bieniasz, P. D. (2009) · Cell · doi:10.1016/j.cell.2009.08.039 · Cited by 590 · see citing works

An Atomic Model of the Interferon-β Enhanceosome

Panne, D., Maniatis, T., & Harrison, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.05.019 · Cited by 625 · see citing works

Host defense, viruses and apoptosis

Barber, G. N. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400823 · Cited by 576 · see citing works

Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.7989-7996.2000 · Cited by 578 · see citing works

Interferon regulatory factors: the next generation

Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 570 · see citing works

Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

Muñoz‐Jordán, J. L., Laurent-Rolle, M., Ashour, J., Martínez‐Sobrido, L., Ashok, M. S., Lipkin, W. I., & García‐Sastre, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.8004-8013.2005 · Cited by 560 · see citing works

Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

Sato, M., Hata, N., Asagiri, M., Nakaya, T., Taniguchi, T., & Tanaka, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01514-2 · Cited by 553 · see citing works

Roles of the NFI/CTF gene family in transcription and development

Gronostajski, R. M. (2000) · Gene · doi:10.1016/s0378-1119(00)00140-2 · Cited by 545 · see citing works

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 540 · see citing works

Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon

Wang, X., Li, M. O., Zheng, H., Muster, T., Palese, P., Beg, A. A., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11566-11573.2000 · Cited by 536 · see citing works

Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes

Grandvaux, N., Servant, M. J., tenOever, B. R., Sen, G. C., Balachandran, S., Barber, G. N., Lin, R., & Hiscott, J. B. (2002) · Journal of Virology · doi:10.1128/jvi.76.11.5532-5539.2002 · Cited by 521 · see citing works

The Human Papillomavirus E6 protein and its contribution to malignant progression

Mantovani, F., & Banks, L. (2001) · Oncogene · doi:10.1038/sj.onc.1204869 · Cited by 511 · see citing works

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bidwell, B. N., Slaney, C. Y., Withana, N. P., Forster, S., Cao, Y., Loi, S., Andrews, D., Mikeska, T., Mangan, N. E., Samarajiwa, S. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2830 · Cited by 487 · see citing works

The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 482 · see citing works

The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3

Basler, C. F., Mikulasova, A., Martínez‐Sobrido, L., Paragas, J., Mühlberger, E., Bray, M., Klenk, H., Palese, P., & García‐Sastre, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.7945-7956.2003 · Cited by 476 · see citing works

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

van Dam, H., & Castellazzi, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204239 · Cited by 462 · see citing works

Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis

Cheung, C. Y., Poon, L. L. M., Ng, I. H. Y., Luk, W., Sia, S. F., Wu, M. H. S., Chan, K., Yuen, K., Gordon, S., Guan, Y., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7819-7826.2005 · Cited by 461 · see citing works

Induction and Regulation of IFNs During Viral Infections

Malmgaard, L. (2004) · Journal of Interferon & Cytokine Research · doi:10.1089/1079990041689665 · Cited by 455 · see citing works

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

Orzalli, M. H., DeLuca, N. A., & Knipe, D. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211302109 · Cited by 422 · see citing works

Interferon-Lambda: A New Addition to an Old Family

Donnelly, R. P., & Kotenko, S. V. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0078 · Cited by 427 · see citing works

Molecular Pathways in Virus-Induced Cytokine Production

Mogensen, T. H., & Paludan, S. R. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.1.131-150.2001 · Cited by 418 · see citing works

Immune Response in Stat2 Knockout Mice

Park, C. Y., Li, S. C., Cha, E., & Schindler, C. (2000) · Immunity · doi:10.1016/s1074-7613(00)00077-7 · Cited by 415 · see citing works

Genome-wide detection of tissue-specific alternative splicing in the human transcriptome

Xu, Q. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf492 · Cited by 415 · see citing works

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412584200 · Cited by 411 · see citing works

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1876 · Cited by 392 · see citing works

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389 · see citing works

Apoptosis Induced by the Toll-Like Receptor Adaptor TRIF Is Dependent on Its Receptor Interacting Protein Homotypic Interaction Motif

Kaiser, W. J., & Offermann, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4942 · Cited by 374 · see citing works

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

Edwards, M. R., Bartlett, N. W., Clarke, D., Birrell, M., Belvisi, M., & Johnston, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.003 · Cited by 375 · see citing works

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Smith, G. L., Benfield, C. T. O., de Motes, C. M., Mazzon, M., Ember, S. W., Ferguson, B. J., & Sumner, R. P. (2013) · Journal of General Virology · doi:10.1099/vir.0.055921-0 · Cited by 365 · see citing works

NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription

Billecocq, A., Spiegel, M., Vialat, P., Kohl, A., Weber, F., Bouloy, M., & Haller, O. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.9798-9806.2004 · Cited by 364 · see citing works

Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression

Julkunen, I. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00026-5 · Cited by 354 · see citing works

Regulation of the type I IFN induction: a current view

Honda, K., Yanai, H., Takaoka, A., & Taniguchi, T. (2005) · International Immunology · doi:10.1093/intimm/dxh318 · Cited by 347 · see citing works

Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

Izaguirre, A. G., Barnes, B. J., Amrute, S. B., Yeow, W.-S., Megjugorac, N. J., Dai, J., Feng, D., Chung, E., Pitha, P. M., & Fitzgerald-Bocarsly, P. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603255 · Cited by 346 · see citing works

Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain

Wathelet, M. G., Orr, M., Frieman, M. B., & Baric, R. S. (2007) · Journal of Virology · doi:10.1128/jvi.00702-07 · Cited by 339 · see citing works

Rip1 Mediates the Trif-dependent Toll-like Receptor 3- and 4-induced NF-κB Activation but Does Not Contribute to Interferon Regulatory Factor 3 Activation

Hermance, N. M., Khurana, S., Lee, T. H.-Y., Fitzgerald, K. A., & Kelliher, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506831200 · Cited by 345 · see citing works

Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity

tenOever, B. R., Ng, S., Chua, M. A., McWhirter, S. M., García‐Sastre, A., & Maniatis, T. (2007) · Science · doi:10.1126/science.1136567 · Cited by 342 · see citing works

Inactivation of Interferon Regulatory Factor-1 Tumor Suppressor Protein by HPV E7 Oncoprotein

Park, J. S., Kim, E., Kwon, H.-J., Hwang, E.-S., Namkoong, S.-E., & Um, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6764 · Cited by 333 · see citing works

Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3

Brzózka, K. D., Finke, S., & Conzelmann, K. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7673-7681.2005 · Cited by 322 · see citing works

Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

Lin, R., Mamane, Y., & Hiscott, J. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2465 · Cited by 321 · see citing works

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80145-8 · Cited by 321 · see citing works

Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses

García‐Sastre, A. (2001) · Virology · doi:10.1006/viro.2000.0756 · Cited by 321 · see citing works

Review: On the Role of IRF in Host Defense

Barnes, B. J., Lubyová, B., & Pitha, P. M. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452665 · Cited by 318 · see citing works

Selective Transcription in Response to an Inflammatory Stimulus

Smale, S. T. (2010) · Cell · doi:10.1016/j.cell.2010.01.037 · Cited by 318 · see citing works

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

Mukherjee, A., Morosky, S. A., Delorme‐Axford, E., Dybdahl-Sissoko, N., Oberste, M. S., Wang, T., & Coyne, C. B. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001311 · Cited by 306 · see citing works

Regulation of immunity and oncogenesis by the IRF transcription factor family

Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298 · see citing works

Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS

Noah, D. L., Twu, K. Y., & Krug, R. M. (2003) · Virology · doi:10.1016/s0042-6822(02)00127-7 · Cited by 302 · see citing works

Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

Au, W.-C., Moore, P. A., LaFleur, D. W., TOMBAL, B. F., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29210 · Cited by 300 · see citing works

RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2

Komuro, A., & Horvath, C. M. (2006) · Journal of Virology · doi:10.1128/jvi.01325-06 · Cited by 298 · see citing works

A FADD-dependent innate immune mechanism in mammalian cells

Balachandran, S., Thomas, E., & Barber, G. N. (2004) · Nature · doi:10.1038/nature03124 · Cited by 294 · see citing works

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

Pandey, A. K., Yang, Y., Jiang, Z., Fortune, S. M., Coulombe, F., Behr, M. A., Fitzgerald, K. A., Sassetti, C. M., & Kelliher, M. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000500 · Cited by 292 · see citing works

Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism

Lin, R.-J., Chang, B.-L., Yu, H.-P., Liao, C., & Lin, Y. (2006) · Journal of Virology · doi:10.1128/jvi.02714-05 · Cited by 286 · see citing works

Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation

Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., & Akira, S. (2002) · International Immunology · doi:10.1093/intimm/dxf089 · Cited by 282 · see citing works

Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3

Spiegel, M., Pichlmair, A., Martínez‐Sobrido, L., Cros, J. F., García‐Sastre, A., Haller, O., & Weber, F. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2079-2086.2005 · Cited by 279 · see citing works

Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

Lin, R., Génin, P., Mamane, Y., & Hiscott, J. B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6342-6353.2000 · Cited by 279 · see citing works

The IRF family, revisited

Paun, A., & Pitha, P. M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.01.014 · Cited by 277 · see citing works

A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines

Jones, C., & Chowdhury, S. I. (2007) · Animal Health Research Reviews · doi:10.1017/s146625230700134x · Cited by 274 · see citing works

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

Lin, R., Heylbroeck, C., Génin, P., Pitha, P., & Hiscott, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.959 · Cited by 325 · see citing works

The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes

Lin, R., Noyce, R. S., Collins, S. E., Everett, R. D., & Mossman, K. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1675-1684.2004 · Cited by 268 · see citing works

Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

Mossman, K. L., Macgregor, P. F., Rozmus, J., Goryachev, A. B., Edwards, A. M., & Smiley, J. R. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.750-758.2001 · Cited by 268 · see citing works

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

Juang, Y.-T., Lowther, W. J., Kellum, M. J., Au, W.-C., Lin, R., Hiscott, J. B., & Pitha, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9837 · Cited by 266 · see citing works

Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

Iwamura, T., Yoneyama, M., Yamaguchi, K., Suhara, W., Mori, W., Shiota, K., Okabe, Y., Namiki, H., & Fujita, T. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00426.x · Cited by 265 · see citing works

Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein

Krug, R. M., Yuan, W., Noah, D. L., & Latham, A. G. (2003) · Virology · doi:10.1016/s0042-6822(03)00119-3 · Cited by 263 · see citing works

Chromatin Immunoprecipitation (ChIP)Preprint

Carey, M., Peterson, C. L., & Smale, S. T. (2009) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5279 · Cited by 263 · see citing works

The enhanceosome

Panne, D. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.12.002 · Cited by 257 · see citing works

The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

Heppner, C., Bilimoria, K. Y., Agarwal, S. K., Kester, M. B., Whitty, L., Guru, S. C., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Marx, S. J., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204529 · Cited by 256 · see citing works

A Lipopolysaccharide-Specific Enhancer Complex Involving Ets, Elk-1, Sp1, and CREB Binding Protein and p300 Is Recruited to the Tumor Necrosis Factor Alpha Promoter In Vivo

Tsai, E. Y., Falvo, J. V., Tsytsykova, A. V., Barczak, A. K., Reimold, A. M., Glimcher, L. H., Fenton, M. J., Gordon, D. C., Dunn, I. F., & Goldfeld, A. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6084-6094.2000 · Cited by 256 · see citing works

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

Parekh, B. S., & Maniatis, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80181-1 · Cited by 255 · see citing works

CS03-5. IRF-1 phosphorylation by I-kappa-B kinase epsilon impairs IFN beta stimulation in activated CD4+ T cells.

Sgarbanti, M., Marsili, G., Remoli, A. L., Sun, Q., Stellacci, E., Mai, A., Rotili, D., Perrotti, E., Orsatti, R., Borsetti, A., et al. (2011) · Cytokine · doi:10.1016/j.cyto.2011.07.318 · Cited by 1 · see citing works

Virus-inducible gene transcription

Heinrichs, A. A. J. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01311-7

Mechanism for transcriptional synergy between interferon regulatory factor (IRF)‐3 and IRF‐7 in activation of the interferon‐β gene promoter

Yang, H., Ma, G., Lin, C. H., Orr, M., & Wathelet, M. G. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04310.x · Cited by 43 · see citing works

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

Sato, M., Tanaka, N., Hata, N., Oda, E., & Taniguchi, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00210-5 · Cited by 264 · see citing works

Synergism between Distinct Enhanson Domains in Viral Induction of the Human Beta Interferon Gene

LEBLANC, J., Cohen, L., Rodrigues, M., & Hiscott, J. B. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.3987 · Cited by 80 · see citing works