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Polymerizing Actin Fibers Position Integrins Primed to Probe for Adhesion Sites
Abstract
Migrating cells extend protrusions, probing the surrounding matrix in search of permissive sites to form adhesions. We found that actin fibers polymerizing along the leading edge directed local protrusions and drove synchronous sideways movement of β 1 integrin adhesion receptors. These movements lead to the clustering and positioning of conformationally activated, but unligated, β 1 integrins along the leading edge of fibroblast lamellae and growth cone filopodia. Thus, rapid actin-based movement of primed integrins along the leading edge suggests a “sticky fingers” mechanism to probe for new adhesion sites and to direct migration.
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Citations
Cited by
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Engineering Substrate Topography at the Micro‐ and Nanoscale to Control Cell Function
Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805179 · Cited by 1,258
Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
Shroff, H., Galbraith, C. G., Galbraith, J. A., & Betzig, E. (2008) · Nature Methods · doi:10.1038/nmeth.1202 · Cited by 873
Self-citationChoi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797
Integrins and the activation of latent transforming growth factor β1 – An intimate relationship
Wipff, P.-J., & Hinz, B. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.012 · Cited by 517
Metadata
- Authors
- Galbraith, C. G., Yamada, K. M., & Galbraith, J. A.
- Venue
- Science
- Published
- 2007-02-16
- Volume
- 315
- Issue
- 5814
- Pages
- 992-995
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966765683
- Cited by
- 301
- References
- 0
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Galbraith, C. G., Yamada, K. M., & Galbraith, J. A. (2007). Polymerizing Actin Fibers Position Integrins Primed to Probe for Adhesion Sites. Science. https://doi.org/10.1126/science.1137904
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
