The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation
Abstract
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8 + effector T cells (cross-presentation) or to CD4 + T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8 + or CD4 + T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.
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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
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Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,455
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
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Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens
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Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate
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Cited by
Cross-presentation by dendritic cells
Joffre, O. P., Segura, E., Savina, A., & Amigorena, S. (2012) · Nature Reviews Immunology · doi:10.1038/nri3254 · Cited by 1,637
Dendritic cell subsets in T cell programming: location dictates function
Eisenbarth, S. C. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0088-1 · Cited by 827
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750
Tseng, D., Volkmer, J.-P., Willingham, S. B., Contreras-Trujillo, H., Fathman, J. W., Fernhoff, N. B., Seita, J., Inlay, M. A., Weiskopf, K., Miyanishi, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305569110 · Cited by 657
Liu, Z., & Roche, P. A. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00001 · Cited by 559
Metadata
- Authors
- Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P. A., & Kurts, C.
- Venue
- Science
- Published
- 2007-04-27
- Volume
- 316
- Issue
- 5824
- Pages
- 612-616
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068206773
- Cited by
- 619
- References
- 32
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P. A., & Kurts, C. (2007). Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation. Science. https://doi.org/10.1126/science.1137971
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
