The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster
Abstract
Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.
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“For example, Drosophila melanogaster that is native to Europe harbors a polymorphism in “timeless,” a key gene in the light response of the circadian system, that follows a latitudinal cline in allele frequency (Sandrelli et al. 2007; Tauber et al. 2007).”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Tauber et al. 2007
Citations
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Bita, C. E., & Gerats, T. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00273 · Cited by 1,896
“Both tapetum and microspore development are essential for male fertility, as documented by numerous studies on male sterile mutants (Prasad et al., 2003; Young et al., 2004; Christensen and Christensen, 2007; Tauber et al., 2007; Ainsworth et al., 2008; Jaggard et al., 2010; Zinn et al., 2010).”
BackgroundToward a synthetic understanding of the role of phenology in ecology and evolution
Forrest, J. R. K., & Miller‐Rushing, A. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0145 · Cited by 766
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Barrett, R. D. H., & Hoekstra, H. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3015 · Cited by 562
“For example, consistent allele frequency differences have been found in Drosophila species across spatial gradient”
BackgroundGenomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila
Bergland, A. O., Behrman, E. L., O’Brien, K. R., SCHMIDT, P. S., & Petrov, D. A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004775 · Cited by 502
Circadian Organization of Behavior and Physiology in Drosophila
Allada, R., & Chung, B. Y. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135815 · Cited by 456
“Naturally occurring variation at the tim locus that alters interactions with cry appears to be important for the tendency to enter this state (58,59).”
Background
Metadata
- Authors
- Tauber, E., Zordan, M., Sandrelli, F., Pegoraro, M., Osterwalder, N., Breda, C., Daga, A., Selmin, A., Monger, K., Benna, C., Rosato, E., Kyriacou, C. P., & Costa, R.
- Affiliations
- University of Padua (IT)
- Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
- Corresponding author
- Tauber, Eran
- Zordan, Mauro
- Sandrelli, Federica
- Daga, Andrea
- Kyriacou, Charalambos P.
- ORCID
- Venue
- Science
- Published
- 2007-06-29
- Volume
- 316
- Issue
- 5833
- Pages
- 1895-1898
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142166311
- Cited by
- 308
- References
- 23
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 8 · 2023: 17 · 2022: 28 · 2021: 11 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 11 · 2014: 15 · 2013: 18 · 2012: 17
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Natural Environment Research Council (NE/D012058/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- timeless gene, circadian clock, natural selection, diapause, life-history traits, seasonal adaptation, Drosophila melanogaster
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Base Sequence, Circadian Rhythm, Drosophila melanogaster, Europe, Female, Geography, Haplotypes, Molecular Sequence Data, Mutation, Phylogeny, Polymorphism, Genetic, Reproduction, Seasons, Selection, Genetic, Temperature, Transformation, Genetic, Photoperiod, Evolution, Molecular, Protein Isoforms, Drosophila Proteins
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