A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster
Abstract
Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly because it enhances diapause. We show that the mutant allele attenuates the photosensitivity of the circadian clock and causes decreased dimerization of the mutant TIMELESS protein isoform to CRYPTOCHROME, the circadian photoreceptor. This interaction results in a more stable TIMELESS product. These findings reveal a molecular link between diapause and circadian photoreception.
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Drosophila melanogaster native to Europe harbors a polymorphism in timeless that follows a latitudinal cline in allele frequency.
“For example, Drosophila melanogaster that is native to Europe harbors a polymorphism in “timeless,” a key gene in the light response of the circadian system, that follows a latitudinal cline in allele frequency (Sandrelli et al. 2007; Tauber et al. 2007).”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Sandrelli et al. 2007
Cites
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Archaic Introgression Shaped Human Circadian Traits
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- Authors
- Sandrelli, F., Tauber, E., Pegoraro, M., Mazzotta, G., Cisotto, P., Landskron, J., Stanewsky, R., Piccin, A., Rosato, E., Zordan, M., Costa, R., & Kyriacou, C. P.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Sandrelli, Federica
- Tauber, Eran
- Pegoraro, Mirko
- ORCID
- Venue
- Science
- Published
- 2007-06-29
- Volume
- 316
- Issue
- 5833
- Pages
- 1898-1900
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979388618
- Cited by
- 205
- References
- 17
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 6 · 2023: 14 · 2022: 28 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 10
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Natural Environment Research Council (NE/D012058/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- timeless gene, diapause, circadian clock, cryptochrome, circadian photoreception, protein stability, natural selection, Drosophila melanogaster
- MeSH terms
- Alleles, Animals, Circadian Rhythm, Climate, Drosophila melanogaster, Europe, Female, Flavoproteins, Light, Motor Activity, Mutation, Seasons, Selection, Genetic, Temperature, Photoperiod, Transgenes, Dimerization, Protein Isoforms, Two-Hybrid System Techniques, Drosophila Proteins, Cryptochromes
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