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Genetic Properties Influencing the Evolvability of Gene Expression
Abstract
Identifying the properties of gene networks that influence their evolution is a fundamental research goal. However, modes of evolution cannot be inferred solely from the distribution of natural variation, because selection interacts with demography and mutation rates to shape polymorphism and divergence. We estimated the effects of naturally occurring mutations on gene expression while minimizing the effect of natural selection. We demonstrate that sensitivity of gene expression to mutations increases with both increasing trans-mutational target size and the presence of a TATA box. Genes with greater sensitivity to mutations are also more sensitive to systematic environmental perturbations and stochastic noise. These results provide a mechanistic basis for gene expression evolvability that can serve as a foundation for realistic models of regulatory evolution.
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Citations
Cites
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
Newman, J. R. S., Ghaemmaghami, S., Ihmels, J., Breslow, D. K., Noble, M., DeRisi, J. L., & Weissman, J. S. (2006) · Nature · doi:10.1038/nature04785 · Cited by 1,483
Slightly Deleterious Mutant Substitutions in Evolution
OHTA, T. (1973) · Nature · doi:10.1038/246096a0 · Cited by 1,104
Cited by
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
López-Maury, L., Marguerat, S., & Bähler, J. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2398 · Cited by 1,061
A genome-wide view of the spectrum of spontaneous mutations in yeast.
Lynch, M., Sung, W., Morris, K., Coffey, N., Landry, C. R., Dopman, E. B., Dickinson, W. J., Okamoto, K., Kulkarni, S., Hartl, D. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803466105 · Cited by 708
Regulatory divergence in Drosophila revealed by mRNA-seq
McManus, C. J., Coolon, J. D., Duff, M. O., Eipper-Mains, J., Graveley, B. R., & Wittkopp, P. J. (2010) · Genome Research · doi:10.1101/gr.102491.109 · Cited by 381
Schroder, K., Irvine, K. M., Taylor, M. S., Bokil, N. J., Le Cao, K.-A., Masterman, K.-A., Labzin, L. I., Semple, C. A., Kapetanovic, R., Fairbairn, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110156109 · Cited by 308
Challenges in measuring and understanding biological noise
Eling, N., Morgan, M. D., & Marioni, J. C. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0130-6 · Cited by 247
The reality and importance of founder speciation in evolution
Templeton, A. R. (2008) · BioEssays · doi:10.1002/bies.20745 · Cited by 245
Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species
Beltrao, P., Trinidad, J. C., Fiedler, D., Roguev, A., Lim, W. A., Shokat, K. M., Burlingame, A. L., & Krogan, N. J. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000134 · Cited by 188
Evolution at two levels of gene expression in yeast
Artieri, C. G., & Fraser, H. B. (2014) · Genome Research · doi:10.1101/gr.165522.113 · Cited by 138
Metadata
- Authors
- Landry, C. R., Lemos, B., Rifkin, S. A., Dickinson, W. J., & Hartl, D. L.
- Venue
- Science
- Published
- 2007-07-06
- Volume
- 317
- Issue
- 5834
- Pages
- 118-121
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081719540
- Cited by
- 318
- References
- 2
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- closed
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