The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis
Abstract
Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1–knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1–independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.
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Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Cited by
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Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
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Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635
The BAR Domain Superfamily: Membrane-Molding Macromolecules
Frost, A., Unger, V. M., & De Camilli, P. (2009) · Cell · doi:10.1016/j.cell.2009.04.010 · Cited by 574
Self-citationDe Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies
Appenzeller, S., Balling, R., Barisic, N., Baulac, S., Caglayan, H., Craiu, D., De Jonghe, P., Depienne, C., Dimova, P., Djémié, T., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.08.013 · Cited by 439
Saheki, Y., & De Camilli, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005645 · Cited by 457
Metadata
- Authors
- Ferguson, S. M., Brasnjo, G., Hayashi, M., Wölfel, M., Collesi, C., Giovedi, S., Raimondi, A., Gong, L.-W., Ariel, P., Paradise, S., O'Toole, E., Flavell, R., Cremona, O., Miesenböck, G., Ryan, T. A., & De Camilli, P.
- Venue
- Science
- Published
- 2007-04-27
- Volume
- 316
- Issue
- 5824
- Pages
- 570-574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079900215
- Cited by
- 515
- References
- 1
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis. https://app.cochat.ai/papers/10.1126/science.1140621
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- Ferguson, S. M., Brasnjo, G., Hayashi, M., Wölfel, M., Collesi, C., Giovedi, S., Raimondi, A., Gong, L.-W., Ariel, P., Paradise, S., O'Toole, E., Flavell, R., Cremona, O., Miesenböck, G., Ryan, T. A., & De Camilli, P. (2007). A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis. Science. https://doi.org/10.1126/science.1140621
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
