The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
Open accessAbstract
Multiple DNA polymerases participate in replicating the leading and lagging strands of the eukaryotic nuclear genome. Although 50 years have passed since the first DNA polymerase was discovered, the identity of the major polymerase used for leading-strand replication is uncertain. We constructed a derivative of yeast DNA polymerase ϵ that retains high replication activity but has strongly reduced replication fidelity, particularly for thymine-deoxythymidine 5'-monophosphate (T-dTMP) but not adenine-deoxyadenosine 5'-monophosphate (A-dAMP) mismatches. Yeast strains with this DNA polymerase ϵ allele have elevated rates of T to A substitution mutations. The position and rate of these substitutions depend on the orientation of the mutational reporter and its location relative to origins of DNA replication and reveal a pattern indicating that DNA polymerase ϵ participates in leading-strand DNA replication.
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Cites
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
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DNA repair pathways as targets for cancer therapy
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Division of Labor at the Eukaryotic Replication Fork
Nick McElhinny, S. A., Gordenin, D. A., Stith, C. M., Burgers, P. M. J., & Kunkel, T. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.022 · Cited by 502
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Metadata
- Authors
- Pursell, Z. F., Isoz, I., Lundström, E.-B., Johansson, E., & Kunkel, T. A.
- Venue
- Science
- Published
- 2007-07-06
- Volume
- 317
- Issue
- 5834
- Pages
- 127-130
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059184834
- Cited by
- 563
- References
- 1
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Pursell, Z. F., Isoz, I., Lundström, E.-B., Johansson, E., & Kunkel, T. A. (2007). Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication. Science. https://doi.org/10.1126/science.1144067
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