The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Label-Free, Single-Molecule Detection with Optical Microcavities
Abstract
Current single-molecule detection techniques require labeling the target molecule. We report a highly specific and sensitive optical sensor based on an ultrahigh quality ( Q ) factor ( Q > 10 8 ) whispering-gallery microcavity. The silica surface is functionalized to bind the target molecule; binding is detected by a resonant wavelength shift. Single-molecule detection is confirmed by observation of single-molecule binding events that shift the resonant frequency, as well as by the statistics for these shifts over many binding events. These shifts result from a thermo-optic mechanism. Additionally, label-free, single-molecule detection of interleukin-2 was demonstrated in serum. These experiments demonstrate a dynamic range of 10 12 in concentration, establishing the microcavity as a sensitive and versatile detector.
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Citations
Cites
Ultra-high-Q toroid microcavity on a chip
Armani, D. K., Kippenberg, T. J., Spillane, S. M., & Vahala, K. J. (2003) · Nature · doi:10.1038/nature01371 · Cited by 2,214
Self-citationWeighing of biomolecules, single cells and single nanoparticles in fluid
Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature · doi:10.1038/nature05741 · Cited by 1,213
Cited by
Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119
Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., Baehr-Jones, T., Bailey, R. C., & Gunn, L. C. (2010) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2009.2032510 · Cited by 551
Fundamental limits and non-reciprocal approaches in non-Hermitian quantum sensing
Lau, H.-K., & Clerk, A. A. (2018) · Nature Communications · doi:10.1038/s41467-018-06477-7 · Cited by 380
Label-free biological and chemical sensors
Hunt, H. K., & Armani, A. M. (2010) · Nanoscale · doi:10.1039/c0nr00201a · Cited by 371
Self-citationPiliarik, M., & Sandoghdar, V. (2014) · Nature Communications · doi:10.1038/ncomms5495 · Cited by 332
Metadata
- Authors
- Armani, A. M., Kulkarni, R. P., Fraser, S. E., Flagan, R. C., & Vahala, K. J.
- Venue
- Science
- Published
- 2007-08-10
- Volume
- 317
- Issue
- 5839
- Pages
- 783-787
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017049373
- Cited by
- 1,141
- References
- 2
- FWCI
- 77.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Armani, A. M., Kulkarni, R. P., Fraser, S. E., Flagan, R. C., & Vahala, K. J. (2007). Label-Free, Single-Molecule Detection with Optical Microcavities. Science. https://doi.org/10.1126/science.1145002
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