The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dynamic Visualization of Thrombopoiesis Within Bone Marrow
Abstract
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy in intact BM to visualize platelet generation in mice. MKs were observed as sessile cells that extended dynamic proplatelet-like protrusions into microvessels. These intravascular extensions appeared to be sheared from their transendothelial stems by flowing blood, resulting in the appearance of proplatelets in peripheral blood. In vitro, proplatelet production from differentiating MKs was enhanced by fluid shear. These results confirm the concept of proplatelet formation in vivo and are consistent with the possibility that blood flow–induced hydrodynamic shear stress is a biophysical determinant of thrombopoiesis.
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Citations
Cites
Thrombopoietin: the primary regulator of platelet production [see comments]
Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642
Cited by
Thrombosis as an intravascular effector of innate immunity
Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
Self-citationPlatelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Yipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 989
Takayama, N., Nishikii, H., Usui, J., Tsukui, H., Sawaguchi, A., Hiroyama, T., Eto, K., & Nakauchi, H. (2008) · Blood · doi:10.1182/blood-2007-10-117622 · Cited by 317
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.
Huang, H., Yu, M., Akie, T. E., Moran, T. B., Woo, A. J., Tu, N., Waldon, Z., Lin, Y. Y., Steen, H., & Cantor, A. B. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00090-09 · Cited by 87
Metadata
- Authors
- Junt, T., Schulze, H., Chen, Z., Massberg, S., Goerge, T., Krueger, A., Wagner, D. D., Graf, T., Italiano, J. E., Shivdasani, R. A., & von Andrian, U. H.
- Venue
- Science
- Published
- 2007-09-21
- Volume
- 317
- Issue
- 5845
- Pages
- 1767-1770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967467568
- Cited by
- 652
- References
- 1
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Junt, T., Schulze, H., Chen, Z., Massberg, S., Goerge, T., Krueger, A., Wagner, D. D., Graf, T., Italiano, J. E., Shivdasani, R. A., & von Andrian, U. H. (2007). Dynamic Visualization of Thrombopoiesis Within Bone Marrow. Science. https://doi.org/10.1126/science.1146304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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