The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression
Abstract
Modifications at the N-terminal tails of nucleosomal histones are required for efficient transcription in vivo. We analyzed how H3 histone methylation and demethylation control expression of estrogen-responsive genes and show that a DNA-bound estrogen receptor directs transcription by participating in bending chromatin to contact the RNA polymerase II recruited to the promoter. This process is driven by receptor-targeted demethylation of H3 lysine 9 at both enhancer and promoter sites and is achieved by activation of resident LSD1 demethylase. Localized demethylation produces hydrogen peroxide, which modifies the surrounding DNA and recruits 8-oxoguanine–DNA glycosylase 1 and topoisomeraseIIβ, triggering chromatin and DNA conformational changes that are essential for estrogen-induced transcription. Our data show a strategy that uses controlled DNA damage and repair to guide productive transcription.
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Cites
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
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Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
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A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription
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Self-citationBeyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619
Endogenous DNA damage as a source of genomic instability in cancer
Tubbs, A., & Nussenzweig, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.002 · Cited by 1,452
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Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920
Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
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Metadata
- Authors
- Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., & Avvedimento, E. V.
- Venue
- Science
- Published
- 2008-01-11
- Volume
- 319
- Issue
- 5860
- Pages
- 202-206
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2138976334
- Cited by
- 527
- References
- 24
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., & Avvedimento, E. V. (2008). DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression. Science. https://doi.org/10.1126/science.1147674
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