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Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate
Open accessAbstract
The limb blastemal cells of an adult salamander regenerate the structures distal to the level of amputation, and the surface protein Prod 1 is a critical determinant of their proximodistal identity. The anterior gradient protein family member nAG is a secreted ligand for Prod 1 and a growth factor for cultured newt blastemal cells. nAG is sequentially expressed after amputation in the regenerating nerve and the wound epidermis—the key tissues of the stem cell niche—and its expression in both locations is abrogated by denervation. The local expression of nAG after electroporation is sufficient to rescue a denervated blastema and regenerate the distal structures. Our analysis brings together the positional identity of the blastema and the classical nerve dependence of limb regeneration.
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Cited by
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0237-2 · Cited by 470
Nerve dependence in tissue, organ, and appendage regeneration
Kumar, A., & Brockes, J. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.003 · Cited by 290
Self-citationComparative regenerative mechanisms across different mammalian tissues
Iismaa, S. E., Kaidonis, X., Nicks, A. M., Bogush, N., Kikuchi, K., Naqvi, N., Harvey, R. P., Husain, A., & Graham, R. M. (2018) · npj Regenerative Medicine · doi:10.1038/s41536-018-0044-5 · Cited by 253
A wound-induced Wnt expression program controls planarian regeneration polarity
Petersen, C. P., & Reddien, P. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906823106 · Cited by 251
Metadata
- Authors
- Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcia, A. A., & Brockes, J. P.
- Venue
- Science
- Published
- 2007-11-02
- Volume
- 318
- Issue
- 5851
- Pages
- 772-777
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2120231073
- Cited by
- 487
- References
- 0
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcia, A. A., & Brockes, J. P. (2007). Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate. Science. https://doi.org/10.1126/science.1147710
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
