Nerve dependence in tissue, organ, and appendage regeneration
Open accessAbstract
Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.
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Without the initial nerve signal, the wound stump heals but no limb grows back in newts.
“Without this initial nerve signal, the wound stump heals, but no limb grows back in newts.”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [131]
Release of nAG from nerves appears to kick-start expression of nAG in the wound epithelium.
“The release of nAG from nerves appears to kick-start expression of nAG in the wound epithelium (131).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [131]
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- Authors
- Kumar, A., & Brockes, J. P.
- Affiliations
- Institute of Structural and Molecular Biology (GB)
- Corresponding author
- Brockes, Jeremy P.
- ORCID
- Brockes, Jeremy P.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 35
- Issue
- 11
- Pages
- 691-699
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2048672935
- Cited by
- 290
- References
- 72
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 25 · 2016: 33 · 2015: 26 · 2014: 24 · 2013: 7
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Neurosciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- tissue regeneration, organ regeneration, appendage regeneration, stem cell niche, glial interactions, salamander regeneration, vertebrate regeneration
- MeSH terms
- Animals, Axons, Denervation, Drosophila melanogaster, Ear, External, Extremities, Fishes, Hydra, Invertebrates, Mice, Inbred Strains, Organ Specificity, Peripheral Nerves, Planarians, Regeneration, Schwann Cells, Species Specificity, Tail, Caudata, Urodela, Vertebrates, Xenopus laevis, Axotomy, Mice
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