The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Trojan Horse Strategy in Agrobacterium Transformation: Abusing MAPK Defense Signaling
Open accessAbstract
Nuclear import of transfer DNA (T-DNA) is a central event in Agrobacterium transformation of plant cells and is thought to occur by the hijacking of certain host cell proteins. The T-DNA–associated virulence protein VirE2 mediates this process by binding to the nuclear import machinery via the host cell factor VIP1, whose role in plants has been so far unknown. Here we show that VIP1 is a transcription factor that is a direct target of the Agrobacterium -induced mitogen-activated protein kinase (MAPK) MPK3. Upon phosphorylation by MPK3, VIP1 relocalizes from the cytoplasm to the nucleus and regulates the expression of the PR1 pathogenesis-related gene. MAPK-dependent phosphorylation of VIP1 is necessary for VIP1-mediated Agrobacterium T-DNA transfer, indicating that Agrobacterium abuses the MAPK-targeted VIP1 defense signaling pathway for nuclear delivery of the T-DNA complex as a Trojan horse.
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MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Innate immunity in plants and animals: striking similarities and obvious differences
Nürnberger, T., Brunner, F., Kemmerling, B., & Piater, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0119.x · Cited by 1,286
Emerging MAP kinase pathways in plant stress signalling
Nakagami, H., Pitzschke, A., & Hirt, H. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.009 · Cited by 676
Self-citationRecognition and Response in the Plant Immune System
Nimchuk, Z., Eulgem, T., Holt III, B. F., & Dangl, J. L. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.142628 · Cited by 604
Jones, D. A., & Takemoto, D. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.016 · Cited by 339
Microbial Elicitors Induce Activation and Dual Phosphorylation of the Arabidopsis thaliana MAPK 6
Nühse, T. S., Peck, S. C., Hirt, H., & Boller, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7521 · Cited by 300
Self-citationRaf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c
Ma, R. Y. M., Tong, T. H. K., Cheung, A. M. S., Tsang, A. C. C., Leung, W. Y., & Yao, K.-M. (2005) · Journal of Cell Science · doi:10.1242/jcs.01657 · Cited by 231
Mészáros, T., Helfer, A., Hatzimasoura, E., Magyar, Z., Serazetdinova, L., Rios, G., Bardóczy, V., Teige, M., Koncz, C., Peck, S., et al. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02888.x · Cited by 198
Disabling surveillance: bacterial type III secretion system effectors that suppress innate immunity
Espinosa, A., & Alfano, J. R. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00452.x · Cited by 165
Biological systems of the host cell involved in Agrobacterium infection
Citovsky, V., Kozlovsky, S. V., Lacroix, B., Zaltsman, A., Dafny-Yelin, M., Vyas, S., Tovkach, A., & Tzfira, T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00830.x · Cited by 159
Cited by
MAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
MAPK cascade signalling networks in plant defence
Pitzschke, A., Schikora, A., & Hirt, H. (2009) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2009.06.008 · Cited by 710
Self-citationQiu, J., Fiil, B. K., Petersen, K., Nielsen, H. B., Botanga, C. J., Thorgrimsen, S., Palma, K., Suarez‐Rodriguez, M. C., Sandbech‐Clausen, S., Lichota, J., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.147 · Cited by 503
Agrobacterium-Mediated Plant Transformation: Biology and Applications
Hwang, H.-H., Yu, M., & Lai, E.-M. (2017) · The Arabidopsis Book · doi:10.1199/tab.0186 · Cited by 312
Hamel, L.-P., Nicole, M.-C., Duplessis, S., & Ellis, B. E. (2012) · The Plant Cell · doi:10.1105/tpc.112.096156 · Cited by 309
Metadata
- Authors
- Djamei, A., Pitzschke, A., Nakagami, H., Rajh, I., & Hirt, H.
- Venue
- Science
- Published
- 2007-10-19
- Volume
- 318
- Issue
- 5849
- Pages
- 453-456
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976059977
- Cited by
- 275
- References
- 10
- FWCI
- 21.56
- Type
- journal article
- Language
- en
- Open access
- green
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